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il-33
IL-33
IL-33 (IL33, chr9p24.1) is a nuclear alarmin of the IL-1 family released by necrotic barrier cells; ST2/IL-1RAcP → MyD88 → NF-κB activates ILC2 and mast cells; IL-33 drives asthma eosinophilia and the atopic march; serum sST2 (decoy receptor) predicts heart failure mortality.
Entry Metadata
| Field | Value |
|---|---|
| ID | il-33 |
| Name | IL-33 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005;23(5):479-490. · PubMed 16286016
- Wechsler ME, Ruddy MK, Pavord ID, et al. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021;385(18):1656-1668. · PubMed 34706177