Atlas One · Host Biology · Scale 07 — System

Asthma

Chronic airway hyperresponsiveness from Th2/ILC2 cytokines (IL-4, IL-5, IL-13), mast cell, and eosinophil activation; reversible bronchoconstriction and airway remodeling. ICS are first-line; dupilumab, mepolizumab, and omalizumab for severe type 2 asthma.

Also known as: bronchial asthma, allergic asthma, eosinophilic asthma, atopic asthma, T2-high asthma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
asthma

Asthma

Chronic airway hyperresponsiveness from Th2/ILC2 cytokines (IL-4, IL-5, IL-13), mast cell, and eosinophil activation; reversible bronchoconstriction and airway remodeling. ICS are first-line; dupilumab, mepolizumab, and omalizumab for severe type 2 asthma.

Entry Metadata

FieldValue
IDasthma
NameAsthma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsRespiratory System connects-toMast Cell connects-toIl 6 connects-toTgf Beta connects-toIge connects-toIl 4 connects-toIl 5 connects-toTslp connects-toIl 33 connects-toPeriostin connects-toAdenosine connects-toCopd connects-toT Helper Cell connects-toAtopic Dermatitis connects-toSmooth Muscle Cell connects-toRespiratory Syncytial Virus connects-toObesity connects-toIl 13 connects-toLung connects-toDendritic Cell connects-toHistamine connects-toNeutrophil connects-toImmune System connects-toNitric Oxide connects-toVitamin D connects-toRegulatory T Cell connects-toCortisol connects-toEpinephrine connects-toCalcium connects-toMagnesium connects-toOxygen connects-toT Cytotoxic Cell connects-toPotassium connects-toSkin connects-toFibrosis connects-toPhoton connects-toProstaglandins connects-toHeart connects-toCollagen connects-toAcetylcholine connects-toAdipocyte connects-toAntibody connects-toReproductive System connects-toGut Microbiome connects-toAspergillus Fumigatus connects-toAnca Vasculitis connects-toIl 17A connects-toFibroblast connects-toBradykinin connects-toStreptococcus Pneumoniae connects-toNf Kb connects-toStat3 connects-toVenous Thromboembolism connects-toCandida Albicans connects-toOsteoporosis connects-toGeneralized Anxiety Disorder connects-toType 2 Diabetes connects-toMajor Depressive Disorder connects-toStroke connects-toPanic Disorder connects-toEndocrine System connects-toInfluenza connects-toNervous System connects-toDigestive System connects-toCardiovascular System connects-toIntegumentary System connects-toMusculoskeletal System connects-toRenal System connects-toCorticosteroids connects-toBeta Blockers connects-toAspirin connects-toTargeted Therapy connects-toLung Slice connects-toCystic Fibrosis connects-toHeart Failure connects-toCardiac Conduction System connects-toAtherosclerosis connects-toGerminal Center connects-toBone Marrow connects-toSars Cov 2 connects-toCovid 19 Disease connects-toPeripheral Nerve connects-toSurfactant connects-toVegf connects-toLeptin connects-toIl 1B connects-toTnf Alpha connects-toCcl2 connects-toIfn Gamma connects-toKit connects-toJak1 2 connects-toSubstance P connects-toS100A8 A9 connects-toEndothelin 1 connects-toAdiponectin connects-toNlrp3 Inflammasome connects-toIl 10 connects-toTlr4 connects-toGlucocorticoid Receptor connects-toMyd88 connects-toErk1 2 connects-toMtor connects-toNfe2L2 connects-toIl 23 connects-toGalectin 3 connects-toSmad4 connects-toStat1 connects-toFoxo connects-toHif 1Alpha connects-toPik3Ca connects-toAkt connects-toGsk 3B connects-toCgas Sting connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toComplement C3 connects-toCxcl12 connects-toArid1A connects-toCalcineurin connects-toEstrogen connects-toComplement C5 connects-toSecretory Iga connects-toXanthine Oxidase connects-toMhc Class Ii connects-toMacrophage connects-toProton connects-toCgrp connects-toTroponin Complex connects-toSelenium connects-toResistin connects-toChloride connects-toType I Interferon connects-toInsulin connects-toZinc connects-toDendritic Cell connects-toCopd connects-toHepcidin connects-toB Cell connects-toIl 12 connects-toNatural Killer Cell connects-toPlasma Cell connects-toIl 31 connects-toPrurigo Nodularis connects-toC5Ar1 connects-toPlatelet connects-toInfluenza A connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toErythropoietin connects-toProlactin connects-toMelatonin connects-toOxytocin connects-toTestosterone connects-toSerotonin connects-toVasopressin connects-toIron connects-toIodine connects-toSodium connects-toCopper connects-toPhosphorus connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toType Ii Pneumocyte connects-toGlutamate connects-toNorepinephrine connects-toIl 2 connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toGhrelin