Atlas One · Host Biology · Scale 07 — System

Cystic Fibrosis

Cystic fibrosis is caused by biallelic CFTR mutations; defective chloride and bicarbonate transport → viscous mucus → progressive bronchiectasis, chronic Pseudomonas infection, and exocrine pancreatic insufficiency; median survival >40 years with CFTR modulator therapy.

Also known as: cystic fibrosis, CF, CFTR disease, CF lung disease, CF bronchiectasis, CF pancreatic insufficiency, CF-related diabetes, CFTR mutation disease, mucoviscidosis, cystic fibrosis Trikafta

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cystic-fibrosis

Cystic Fibrosis

Cystic fibrosis is caused by biallelic CFTR mutations; defective chloride and bicarbonate transport → viscous mucus → progressive bronchiectasis, chronic Pseudomonas infection, and exocrine pancreatic insufficiency; median survival >40 years with CFTR modulator therapy.

Entry Metadata

FieldValue
IDcystic-fibrosis
NameCystic Fibrosis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCftr connects-toPrss1 connects-toTgf Beta connects-toNlrp3 Inflammasome connects-toNeutrophil connects-toIl 1B connects-toHereditary Pancreatitis connects-toChloride connects-toLung connects-toStaphylococcus Aureus connects-toPancreas connects-toCopd connects-toType 2 Diabetes connects-toRespiratory System connects-toDigestive System connects-toReproductive System connects-toSodium connects-toAspergillus Fumigatus connects-toLiver connects-toSmall Intestine connects-toEndocrine System connects-toOsteoporosis connects-toFibrosis connects-toMacrophage connects-toImmune System connects-toVitamin D connects-toInsulin connects-toMagnesium connects-toNf Kb connects-toT Helper Cell connects-toOxygen connects-toHydrogen connects-toLarge Intestine connects-toFibroblast connects-toPhoton connects-toSkin connects-toIntestinal Epithelium connects-toElectron connects-toHeart connects-toKidney connects-toStomach connects-toAntibody connects-toErythrocyte connects-toSpleen connects-toOsteoclast connects-toIron connects-toType 1 Diabetes connects-toIl 6 connects-toDendritic Cell connects-toIl 17A connects-toSepsis connects-toMast Cell connects-toColorectal Cancer connects-toPulmonary Arterial Hypertension connects-toStat3 connects-toCkd connects-toPancreatic Cancer connects-toMajor Depressive Disorder connects-toVenous Thromboembolism connects-toHcc connects-toGeneralized Anxiety Disorder connects-toIntegumentary System connects-toHeart Failure connects-toMusculoskeletal System connects-toNervous System connects-toCardiovascular System connects-toRenal System connects-toMycobacterium Tuberculosis connects-toClostridioides Difficile connects-toZinc Dietary connects-toVancomycin connects-toAmoxicillin connects-toAsthma connects-toTargeted Therapy connects-toLung Slice connects-toIslet Of Langerhans connects-toHepatic Lobule connects-toAnemia Of Chronic Disease connects-toCortical Bone connects-toAspergillus Fumigatus connects-toInfluenza connects-toAlveolus connects-toTnf Alpha connects-toHepatocyte connects-toSurfactant connects-toCcl2 connects-toHif 1Alpha connects-toVegf connects-toS100A8 A9 connects-toAutophagy connects-toRankl connects-toTlr4 connects-toEgfr connects-toNitric Oxide connects-toSecretory Iga connects-toXanthine Oxidase connects-toCaspase 3 connects-toNfe2L2 connects-toIl 10 connects-toComplement C3 connects-toMyd88 connects-toMtor connects-toJak1 2 connects-toAkt connects-toErk1 2 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toGsk 3B connects-toPerforin connects-toPik3Ca connects-toAmpk connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toComplement C5 connects-toCxcl12 connects-toIl 33 connects-toCollagen connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toPotassium connects-toCalcium connects-toMhc Class Ii connects-toProton connects-toIl 13 connects-toTroponin Complex connects-toProstaglandins connects-toZinc connects-toCholesterol connects-toOmega 3 Fatty Acids connects-toIl 4 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toHepcidin connects-toLiver connects-toSodium connects-toOsteoporosis connects-toAspergillus Fumigatus connects-toType Ii Pneumocyte connects-toType I Interferon connects-toIl 5 connects-toIl 12 connects-toIl 23 connects-toC5Ar1 connects-toIge connects-toAspergillus Fumigatus connects-toFactor H connects-toTransferrin connects-toPeriostin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toSelenium connects-toIodine connects-toCopper connects-toPhosphorus connects-toSulfur connects-toCarbon connects-toNitrogen connects-toAkt connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources