Atlas One · Host Biology · Scale 07 — System

Hereditary Pancreatitis

Hereditary pancreatitis is caused by autosomal dominant PRSS1 gain-of-function mutations (R122H, N29I); recurrent acute pancreatitis from childhood; chronic pancreatitis with exocrine and endocrine insufficiency; ~40-fold elevated PDAC risk; analgesic-focused management.

Also known as: hereditary pancreatitis, hereditary chronic pancreatitis, PRSS1 pancreatitis, familial pancreatitis, trypsinogen R122H pancreatitis, hereditary pancreatitis PRSS1, HP pancreatitis, chronic hereditary pancreatitis, pancreatitis hereditary syndrome

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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hereditary-pancreatitis

Hereditary Pancreatitis

Hereditary pancreatitis is caused by autosomal dominant PRSS1 gain-of-function mutations (R122H, N29I); recurrent acute pancreatitis from childhood; chronic pancreatitis with exocrine and endocrine insufficiency; ~40-fold elevated PDAC risk; analgesic-focused management.

Entry Metadata

FieldValue
IDhereditary-pancreatitis
NameHereditary Pancreatitis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPrss1 connects-toPancreatic Cancer connects-toTgf Beta connects-toKras connects-toPancreas connects-toCftr connects-toInsulin connects-toCystic Fibrosis connects-toFibroblast connects-toAlcohol Use Disorder connects-toType 2 Diabetes connects-toDigestive System connects-toSmall Intestine

Sources