Atlas One · Host Biology · Scale 07 — System

Hereditary Pancreatitis

Hereditary pancreatitis is caused by autosomal dominant PRSS1 gain-of-function mutations (R122H, N29I); recurrent acute pancreatitis from childhood; chronic pancreatitis with exocrine and endocrine insufficiency; ~40-fold elevated PDAC risk; analgesic-focused management.

Also known as: hereditary pancreatitis, hereditary chronic pancreatitis, PRSS1 pancreatitis, familial pancreatitis, trypsinogen R122H pancreatitis, hereditary pancreatitis PRSS1, HP pancreatitis, chronic hereditary pancreatitis, pancreatitis hereditary syndrome

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hereditary-pancreatitis

Hereditary Pancreatitis

Hereditary pancreatitis is caused by autosomal dominant PRSS1 gain-of-function mutations (R122H, N29I); recurrent acute pancreatitis from childhood; chronic pancreatitis with exocrine and endocrine insufficiency; ~40-fold elevated PDAC risk; analgesic-focused management.

Entry Metadata

FieldValue
IDhereditary-pancreatitis
NameHereditary Pancreatitis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPrss1 connects-toPancreatic Cancer connects-toTgf Beta connects-toKras connects-toPancreas connects-toCftr connects-toInsulin connects-toCystic Fibrosis connects-toFibroblast connects-toAlcohol Use Disorder connects-toType 2 Diabetes connects-toDigestive System connects-toSmall Intestine connects-toCalcium connects-toNlrp3 Inflammasome connects-toType 1 Diabetes connects-toMacrophage connects-toLiver connects-toGlucagon connects-toFibrosis connects-toNeutrophil connects-toNervous System connects-toVitamin D connects-toMagnesium connects-toEndocrine System connects-toAutophagy connects-toCarbon connects-toZinc connects-toNf Kb connects-toIl 6 connects-toDendritic Cell connects-toSpleen connects-toAdipocyte connects-toLung connects-toPhoton connects-toKidney connects-toIntestinal Epithelium connects-toElectron connects-toStomach connects-toBone Marrow connects-toNeuron connects-toLarge Intestine connects-toErythrocyte connects-toOsteoporosis connects-toP53 connects-toPlatelet connects-toTnf Alpha connects-toVenous Thromboembolism connects-toArds connects-toNeuropathic Pain connects-toOpioid Use Disorder connects-toMast Cell connects-toStat3 connects-toSepsis connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toCkd connects-toCholangiocarcinoma connects-toIron Deficiency Anemia connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toIntegumentary System connects-toMusculoskeletal System connects-toRenal System connects-toCardiovascular System connects-toLymphatic System connects-toImmune System connects-toReproductive System connects-toIbuprofen connects-toEscherichia Coli connects-toCancer Chemotherapy connects-toIslet Of Langerhans connects-toHereditary Angioedema connects-toCurcumin connects-toAlveolus connects-toHepatic Lobule connects-toPeripheral Nerve connects-toCortical Bone connects-toCytokine Storm connects-toArterial Wall connects-toCovid 19 Disease connects-toCalcineurin connects-toEgfr connects-toEndothelin 1 connects-toIl 1B connects-toCcl2 connects-toHif 1Alpha connects-toPdgf connects-toS100A8 A9 connects-toTert connects-toCaspase 3 connects-toTlr4 connects-toBradykinin connects-toCalcium connects-toCollagen connects-toXanthine Oxidase connects-toErk1 2 connects-toMyd88 connects-toSmad4 connects-toJak1 2 connects-toNfe2L2 connects-toCdkn2A connects-toAkt connects-toMtor connects-toGalectin 3 connects-toCgas Sting connects-toStat1 connects-toPik3Ca connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toPerforin connects-toAmpk connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toArid1A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toAdenosine connects-toOsteopontin connects-toMu Opioid Receptor connects-toSubstance P connects-toMhc Class Ii connects-toHemoglobin connects-toGlp 1 connects-toProstaglandins connects-toIl 10 connects-toCholesterol connects-toSelenium connects-toIl 4 connects-toIl 13 connects-toIron connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toT Cytotoxic Cell connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toC5Ar1 connects-toComplement C5 connects-toTransferrin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toTslp connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toCopper connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toNitrogen connects-toOxygen connects-toSulfur connects-toHydrogen connects-toPd 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toVegf connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources