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cdkn2a
CDKN2A
CDKN2A at 9p21 encodes p16/INK4A (CDK4/6 inhibitor → RB1 G1 checkpoint) and p14/ARF (MDM2 inhibitor → p53 stabilization); homozygous deletion in ~50% melanoma, ~60% glioblastoma, ~80% PDAC; germline p16 mutations cause FAMMM; CDK4/6 inhibitors exploit p16 loss.
Entry Metadata
| Field | Value |
|---|---|
| ID | cdkn2a |
| Name | CDKN2A |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |