Atlas One · Host Biology · Scale 07 — System

Melanoma

Skin cancer from melanocytes; BRAF V600E (50%) and NRAS Q61 (25%) are dominant drivers. Dual checkpoint blockade (nivolumab + ipilimumab) and BRAF+MEK inhibitors (dabrafenib+trametinib) each achieve ~50-60% responses; 5-year OS ~50% in the immunotherapy era.

Also known as: cutaneous melanoma, malignant melanoma, uveal melanoma, acral melanoma, mucosal melanoma, BRAF-mutant melanoma, metastatic melanoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
melanoma

Melanoma

Skin cancer from melanocytes; BRAF V600E (50%) and NRAS Q61 (25%) are dominant drivers. Dual checkpoint blockade (nivolumab + ipilimumab) and BRAF+MEK inhibitors (dabrafenib+trametinib) each achieve ~50-60% responses; 5-year OS ~50% in the immunotherapy era.

Entry Metadata

FieldValue
IDmelanoma
NameMelanoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toBraf connects-toPd 1 connects-toCtla 4 connects-toPten connects-toAdenosine connects-toPerforin damaged-byPhoton connects-toNsclc connects-toSkin connects-toT Cytotoxic Cell connects-toUveal Melanoma connects-toImmune System connects-toBrain connects-toLymphatic System connects-toBasal Cell Carcinoma connects-toCdkn2A connects-toNatural Killer Cell connects-toLiver connects-toNf1 connects-toIntegumentary System connects-toEye connects-toNervous System connects-toKit connects-toDendritic Cell connects-toAkt connects-toErk1 2 connects-toRegulatory T Cell connects-toMacrophage connects-toOxygen connects-toLung connects-toVegf connects-toCopper connects-toFibrosis connects-toSmall Intestine connects-toTert connects-toElectron connects-toAdrenal Gland connects-toHeart connects-toBone Marrow connects-toStomach connects-toAntibody connects-toVitamin D connects-toNeutrophil connects-toThyroid connects-toReproductive System connects-toPlatelet connects-toIl 2 connects-toType 1 Diabetes connects-toFibroblast connects-toStat3 connects-toEndocrine System connects-toMast Cell connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toCytokine Storm connects-toStroke connects-toMajor Depressive Disorder connects-toHeart Failure connects-toCkd connects-toGeneralized Anxiety Disorder connects-toDigestive System connects-toRespiratory System connects-toWound Healing connects-toCardiovascular System connects-toMusculoskeletal System connects-toRenal System connects-toTargeted Therapy connects-toLi Fraumeni Syndrome connects-toHereditary Breast Ovarian Cancer connects-toCheckpoint Inhibitors connects-toParkinsons Disease connects-toCancer Chemotherapy connects-toGerminal Center connects-toGist connects-toThyroid Cancer connects-toPancreatic Cancer connects-toMyocardium connects-toHepatic Lobule connects-toColorectal Cancer connects-toInflammatory Bowel Disease connects-toEpilepsy connects-toWnt Beta Catenin connects-toCyclin D1 connects-toMtor connects-toMyc connects-toHif 1Alpha connects-toEzh2 connects-toIfn Gamma connects-toTgf Beta connects-toCcl2 connects-toCgas Sting connects-toCxcl12 connects-toCaspase 3 connects-toEndothelin 1 connects-toDnmt3A connects-toIgf 1 connects-toCdk4 6 connects-toPik3Ca connects-toKras connects-toJak1 2 connects-toNfe2L2 connects-toMyd88 connects-toGalectin 3 connects-toSmad4 connects-toStat1 connects-toGsk 3B connects-toFoxo connects-toYap1 connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toIl 6 connects-toNotch connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toMhc Class Ii connects-toAxl Receptor connects-toTroponin Complex connects-toIl 10 connects-toXanthine Oxidase connects-toT Helper Cell connects-toProstaglandins connects-toIl 4 connects-toNitric Oxide connects-toIl 13 connects-toIron connects-toZinc connects-toType I Interferon connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIl 12 connects-toIl 5 connects-toPlasma Cell connects-toIl 23 connects-toIge connects-toB Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toTslp connects-toPeriostin connects-toHistamine connects-toBradykinin connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCalcium connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toNitrogen connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toNotch connects-toIgf 1 connects-toTgf Beta connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources