Atlas One · Host Biology · Scale 03 — Molecular

CCL2

CCL2 (MCP-1, chr17q12) is the dominant monocyte chemoattractant; CCR2 → Gαi → PI3K/Akt + MAPK → directed migration; drives atherosclerotic plaque monocyte infiltration, NASH-associated macrophage (Kupffer cell) activation, and IgA nephropathy tubulointerstitial fibrosis.

Also known as: CCL2, MCP-1, monocyte chemoattractant protein-1, MCAF, HC11, SMC-CF, JE protein, CCR2 ligand

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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ccl2

CCL2

CCL2 (MCP-1, chr17q12) is the dominant monocyte chemoattractant; CCR2 → Gαi → PI3K/Akt + MAPK → directed migration; drives atherosclerotic plaque monocyte infiltration, NASH-associated macrophage (Kupffer cell) activation, and IgA nephropathy tubulointerstitial fibrosis.

Entry Metadata

FieldValue
IDccl2
NameCCL2
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAtherosclerosis connects-toIga Nephropathy connects-toNash connects-toCardiovascular System connects-toRheumatoid Arthritis connects-toType 2 Diabetes

Sources