Atlas One · Host Biology · Scale 07 — System

NASH

Metabolic liver disease from steatosis (NAFLD) through steatohepatitis (NASH) to fibrosis and HCC; driven by insulin resistance and hepatic lipid overload. TGF-beta activates stellate cells → fibrosis; semaglutide and resmetirom (THR-beta agonist) are approved treatments.

Also known as: nonalcoholic steatohepatitis, NAFLD, nonalcoholic fatty liver disease, MASLD, MASH, metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, hepatic steatosis

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
nash

NASH

Metabolic liver disease from steatosis (NAFLD) through steatohepatitis (NASH) to fibrosis and HCC; driven by insulin resistance and hepatic lipid overload. TGF-beta activates stellate cells → fibrosis; semaglutide and resmetirom (THR-beta agonist) are approved treatments.

Entry Metadata

FieldValue
IDnash
NameNASH
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTgf Beta connects-toMacrophage connects-toHepatocyte connects-toInsulin Receptor connects-toGlp 1 connects-toAdiponectin connects-toResistin connects-toCcl2 connects-toIl 10 connects-toPeriostin connects-toFibronectin connects-toType 2 Diabetes connects-toObesity connects-toHcc connects-toLiver connects-toCardiovascular System connects-toHepatitis C connects-toFibrosis connects-toInsulin connects-toFibroblast connects-toGut Microbiome connects-toThyroid Hormones connects-toCholesterol connects-toSglt2 connects-toAlcohol Use Disorder connects-toT Cytotoxic Cell connects-toNlrp3 Inflammasome connects-toIron connects-toNatural Killer Cell connects-toAdipocyte connects-toSpleen connects-toOxygen connects-toPhoton connects-toHeart connects-toSodium connects-toElectron connects-toKidney connects-toVitamin D connects-toCollagen connects-toBrain connects-toNeutrophil connects-toReproductive System connects-toDietary Fiber connects-toEndothelial Cell connects-toTnf Alpha connects-toB Cell connects-toCkd connects-toAtherosclerosis connects-toLeptin connects-toIl 6 connects-toNf Kb connects-toStat3 connects-toVenous Thromboembolism connects-toColorectal Cancer connects-toHeart Failure connects-toGout connects-toStroke connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toDigestive System connects-toNervous System connects-toEndocrine System connects-toRespiratory System connects-toMusculoskeletal System connects-toImmune System connects-toIntegumentary System connects-toLymphatic System connects-toRenal System connects-toMetformin connects-toOmega 3 Fatty Acids connects-toCurcumin connects-toHepatic Lobule connects-toStatins connects-toCheckpoint Inhibitors connects-toArterial Wall connects-toIslet Of Langerhans connects-toPsoriasis connects-toHepatitis B connects-toMyocardium connects-toCholangiocarcinoma connects-toCardiac Conduction System connects-toCovid 19 Disease connects-toIntestinal Epithelium connects-toHif 1Alpha connects-toVegf connects-toEndothelin 1 connects-toPdgf connects-toIl 1B connects-toCgas Sting connects-toTlr4 connects-toGalectin 3 connects-toCaspase 3 connects-toFgfr connects-toHepcidin connects-toXanthine Oxidase connects-toAkt connects-toAmpk connects-toNfe2L2 connects-toMtor connects-toSmad4 connects-toMyd88 connects-toJak1 2 connects-toComplement C3 connects-toPten connects-toStat1 connects-toErk1 2 connects-toEzh2 connects-toFoxo connects-toS100A8 A9 connects-toCdk4 6 connects-toGsk 3B connects-toPerforin connects-toSrc Kinase connects-toPik3Ca connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 17A connects-toIl 33 connects-toArid1A connects-toCalcineurin connects-toAxl Receptor connects-toPcsk9 connects-toBcl 2 connects-toTroponin Complex connects-toPancreas connects-toEstrogen connects-toNitric Oxide connects-toAldosterone connects-toProstaglandins connects-toObesity connects-toHcc connects-toIron connects-toIl 4 connects-toIl 13 connects-toCopper connects-toAtherosclerosis connects-toZinc connects-toSelenium connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toMast Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toMagnesium connects-toCalcium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toPd 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin