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osteoporosis
Osteoporosis
Skeletal disease of low bone density and microarchitectural deterioration → fragility fractures. Driven by estrogen deficiency and osteoclast-osteoblast uncoupling; bisphosphonates, denosumab (RANKL inhibitor), and romosozumab (anti-sclerostin) reduce fracture risk.
Entry Metadata
| Field | Value |
|---|---|
| ID | osteoporosis |
| Name | Osteoporosis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toTgf Beta
connects-toIl 6
connects-toCollagen
connects-toOsteoclast
connects-toFgf23
connects-toPth
connects-toCalcitonin
connects-toRankl
connects-toSclerostin
connects-toTestosterone
connects-toEstrogen
connects-toThyroid Hormones
connects-toOsteoblast
connects-toMusculoskeletal System
connects-toReproductive System
connects-toCalcium
connects-toVitamin D
connects-toCortisol
connects-toBone Marrow
connects-toMagnesium
connects-toEndocrine System
connects-toPhosphorus
connects-toRheumatoid Arthritis
connects-toDigestive System
connects-toAdipocyte
connects-toMultiple Myeloma
connects-toKidney
connects-toWnt Beta Catenin
connects-toSmall Intestine
connects-toSerotonin
connects-toPhoton
connects-toStomach
connects-toSodium
connects-toMacrophage
connects-toLiver
connects-toZinc
connects-toElectron
connects-toLung
connects-toLarge Intestine
connects-toNeuron
connects-toHeart
connects-toSkin
connects-toAntibody
connects-toAnorexia Nervosa
connects-toAdrenal Gland
connects-toCkd
connects-toGrowth Hormone
connects-toT Cytotoxic Cell
connects-toType 1 Diabetes
connects-toLeptin
connects-toEndothelial Cell
connects-toNf Kb
connects-toCopd
connects-toInflammatory Bowel Disease
connects-toProstate Cancer
connects-toBreast Cancer
connects-toEpilepsy
connects-toType 2 Diabetes
connects-toWound Healing
connects-toMajor Depressive Disorder
connects-toImmune System
connects-toStroke
connects-toGvhd
connects-toRespiratory System
connects-toNervous System
connects-toCardiovascular System
connects-toRenal System
connects-toMagnesium Dietary
connects-toIntegumentary System
connects-toCorticosteroids
connects-toAnkylosing Spondylitis
connects-toHiv 1
connects-toTargeted Therapy
connects-toCortical Bone
connects-toCancer Chemotherapy
connects-toArterial Wall
connects-toOmeprazole
connects-toOpioid Use Disorder
connects-toAlcohol Use Disorder
connects-toParkinsons Disease
connects-toWerner Syndrome
connects-toThalassemia
connects-toIntestinal Epithelium
connects-toMen1 Syndrome
connects-toIgf 1
connects-toTnf Alpha
connects-toIl 1B
connects-toGlucocorticoid Receptor
connects-toOsteopontin
connects-toVegf
connects-toCaspase 3
connects-toProstaglandins
connects-toNitric Oxide
connects-toCalcium
connects-toMyostatin
connects-toAdiponectin
connects-toNotch
connects-toHif 1Alpha
connects-toNfe2L2
connects-toIl 17A
connects-toAkt
connects-toMyd88
connects-toMtor
connects-toErk1 2
connects-toJak1 2
connects-toGalectin 3
connects-toStat3
connects-toSmad4
connects-toFoxo
connects-toStat1
connects-toCgas Sting
connects-toGsk 3B
connects-toPik3Ca
connects-toS100A8 A9
connects-toAmpk
connects-toAutophagy
connects-toSrc Kinase
connects-toDnmt3A
connects-toCcr5
connects-toCxcl12
connects-toIl 33
connects-toComplement C3
connects-toArid1A
connects-toZinc
connects-toBcl 2
connects-toInsulin
connects-toProgesterone
connects-toXanthine Oxidase
connects-toMu Opioid Receptor
connects-toGlp 1
connects-toAldosterone
connects-toIl 10
connects-toBone Marrow
connects-toMagnesium
connects-toIl 4
connects-toCopper
connects-toIl 13
connects-toResistin
connects-toCortical Bone
connects-toPhosphorus
connects-toVitamin D
connects-toIfn Gamma
connects-toIl 12
connects-toType I Interferon
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Helper Cell
connects-toMast Cell
connects-toB Cell
connects-toComplement C5
connects-toC5Ar1
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toMelatonin
connects-toC1 Esterase Inhibitor
connects-toFactor H
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toPotassium
connects-toIron
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toCarbon
connects-toHydrogen
connects-toOxygen
connects-toPd 1
connects-toAngiotensin Ii
connects-toIl 2
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toFibronectin
connects-toActivin A
connects-toCgrp
connects-toSubstance P
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toAngiopoietin
connects-toGhrelin
connects-toGlucagon
Sources
- Kanis JA, Cooper C, Rizzoli R, Reginster JY; Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2019;30(1):3-44. · PubMed 30324412
- Cosman F, Crittenden DB, Adachi JD, et al. Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med. 2016;375(16):1532-1543. · PubMed 27641143
- Cummings SR, San Martin J, McClung MR, et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009;361(8):756-765. · PubMed 19671655