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omeprazole
Omeprazole
Proton pump inhibitor (PPI); irreversibly inactivates H⁺/K⁺-ATPase on parietal cells → ≥95% acid suppression. First-line for peptic ulcer, GERD, Zollinger-Ellison syndrome, and H. pylori eradication. Sold as Prilosec/Losec.
Entry Metadata
| Field | Value |
|---|---|
| ID | omeprazole |
| Name | Omeprazole |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Stream | 01-modern |
Cross-Atlas Connections
Sources
- Fellenius E, Berglindh T, Sachs G, et al. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature. 1981;290(5802):159-61. · PubMed 7207579
- Hunt RH, Fallone C, Veldhuyzen van Zanten S, et al. Etiology of peptic ulcer disease — new approach. Eur J Gastroenterol Hepatol. 1999;11 Suppl 2:S5-11. · PubMed 10575154
- Moayyedi P, Santana J, Khan M, Preston C, Donnellan C. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database Syst Rev. 2007;(2):CD003244. · PubMed 17443527
- Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;71(9):1724-1762. · PubMed 35707400