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gvhd
Graft-Versus-Host Disease
GvHD occurs when donor T cells recognize host alloantigens after allogeneic HSCT; acute (skin, gut, liver, <100 days) vs. chronic (fibrotic, >100 days). IL-10/Treg axis is protective; ruxolitinib (JAK1/2) is the approved steroid-refractory treatment.
Entry Metadata
| Field | Value |
|---|---|
| ID | gvhd |
| Name | Graft-Versus-Host Disease |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toIl 10
connects-toBone Marrow
connects-toIl 6
connects-toT Helper Cell
connects-toT Cytotoxic Cell
connects-toGut Microbiome
connects-toSkin
connects-toJak1 2
connects-toRegulatory T Cell
connects-toAhus
connects-toAml
connects-toLiver
connects-toSystemic Sclerosis
connects-toSjogrens Syndrome
connects-toDendritic Cell
connects-toCytokine Storm
connects-toNatural Killer Cell
connects-toLung
connects-toLarge Intestine
connects-toCalcineurin
connects-toImmune System
connects-toEye
connects-toMhc Class Ii
connects-toB Cell
connects-toIntestinal Epithelium
connects-toThymus
connects-toTnf Alpha
connects-toFibroblast
connects-toPerforin
connects-toPhoton
connects-toPotassium
connects-toFibrosis
connects-toMacrophage
connects-toMagnesium
connects-toIl 2
connects-toPeripheral Nerve
connects-toElectron
connects-toStomach
connects-toKidney
connects-toAntibody
connects-toMusculoskeletal System
connects-toReproductive System
connects-toCortisol
connects-toHepatocyte
connects-toThyroid
connects-toIl 17A
connects-toSmall Intestine
connects-toMds
connects-toIfn Gamma
connects-toStat1
connects-toAll
connects-toNf Kb
connects-toStat3
connects-toSepsis
connects-toAspergillus Fumigatus
connects-toPneumocystis Jirovecii
connects-toCkd
connects-toWound Healing
connects-toOsteoporosis
connects-toMajor Depressive Disorder
connects-toIntegumentary System
connects-toDigestive System
connects-toRespiratory System
connects-toNervous System
connects-toEndocrine System
connects-toRenal System
connects-toLymphatic System
connects-toCardiovascular System
connects-toVaricella Zoster Virus
connects-toCorticosteroids
connects-toHerpesvirus
connects-toDietary Fiber
connects-toTargeted Therapy
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toAplastic Anemia
connects-toHepatic Lobule
connects-toGerminal Center
connects-toAlveolus
connects-toDlbcl
connects-toMyelofibrosis
connects-toCovid 19 Disease
connects-toThrombotic Thrombocytopenic Purpura
connects-toDermatomyositis
connects-toTgf Beta
connects-toIl 1B
connects-toNlrp3 Inflammasome
connects-toMtor
connects-toTlr4
connects-toS100A8 A9
connects-toBtk
connects-toCcl2
connects-toCaspase 3
connects-toIl 33
connects-toBaff
connects-toPeriostin
connects-toNotch
connects-toAkt
connects-toIl 12
connects-toCgas Sting
connects-toPd 1
connects-toPdgf
connects-toErk1 2
connects-toSmad4
connects-toGalectin 3
connects-toPik3Ca
connects-toEzh2
connects-toCxcl12
connects-toFoxo
connects-toHif 1Alpha
connects-toCdk4 6
connects-toGsk 3B
connects-toSrc Kinase
connects-toDnmt3A
connects-toAmpk
connects-toAutophagy
connects-toCcr5
connects-toComplement C3
connects-toAdenosine
connects-toCd20
connects-toArid1A
connects-toOsteopontin
connects-toType I Interferon
connects-toCtla 4
connects-toSecretory Iga
connects-toBcl 2
connects-toCollagen
connects-toIl 13
connects-toHemoglobin
connects-toProstaglandins
connects-toIl 4
connects-toXanthine Oxidase
connects-toIron
connects-toHepcidin
connects-toNitric Oxide
connects-toVegf
connects-toComplement C5
connects-toIl 5
connects-toLiver
connects-toT Helper Cell
connects-toSystemic Sclerosis
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toIl 23
connects-toIge
connects-toPlasma Cell
connects-toC5Ar1
connects-toMast Cell
connects-toNeutrophil
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toProlactin
connects-toTestosterone
connects-toSerotonin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toZinc
connects-toSodium
connects-toCopper
connects-toCalcium
connects-toChloride
connects-toNitrogen
connects-toPhosphorus
connects-toCarbon
connects-toHydrogen
connects-toOxygen
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toFibronectin
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toFgfr
connects-toEpinephrine
Sources
- Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373(9674):1550-1561. · PubMed 19380114
- Zeiser R, von Bubnoff N, Butler J, et al. Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease. N Engl J Med. 2020;382(19):1800-1810. · PubMed 32374962
- Przepiorka D, Luo L, Subramaniam S, et al. FDA Approval Summary: Ruxolitinib for Treatment of Chronic Graft-versus-Host Disease. Oncologist. 2022;27(2):98-104. · PubMed 35641197