Atlas One · Host Biology · Scale 07 — System

Graft-Versus-Host Disease

GvHD occurs when donor T cells recognize host alloantigens after allogeneic HSCT; acute (skin, gut, liver, <100 days) vs. chronic (fibrotic, >100 days). IL-10/Treg axis is protective; ruxolitinib (JAK1/2) is the approved steroid-refractory treatment.

Also known as: GvHD, graft versus host disease, GVHD, acute GvHD, chronic GvHD, aGvHD, cGvHD

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
gvhd

Graft-Versus-Host Disease

GvHD occurs when donor T cells recognize host alloantigens after allogeneic HSCT; acute (skin, gut, liver, <100 days) vs. chronic (fibrotic, >100 days). IL-10/Treg axis is protective; ruxolitinib (JAK1/2) is the approved steroid-refractory treatment.

Entry Metadata

FieldValue
IDgvhd
NameGraft-Versus-Host Disease
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toIl 10 connects-toBone Marrow connects-toIl 6 connects-toT Helper Cell connects-toT Cytotoxic Cell connects-toGut Microbiome connects-toSkin connects-toJak1 2 connects-toRegulatory T Cell connects-toAhus connects-toAml connects-toLiver connects-toSystemic Sclerosis connects-toSjogrens Syndrome connects-toDendritic Cell connects-toCytokine Storm connects-toNatural Killer Cell connects-toLung connects-toLarge Intestine connects-toCalcineurin connects-toImmune System connects-toEye connects-toMhc Class Ii connects-toB Cell connects-toIntestinal Epithelium connects-toThymus connects-toTnf Alpha connects-toFibroblast connects-toPerforin connects-toPhoton connects-toPotassium connects-toFibrosis connects-toMacrophage connects-toMagnesium connects-toIl 2 connects-toPeripheral Nerve connects-toElectron connects-toStomach connects-toKidney connects-toAntibody connects-toMusculoskeletal System connects-toReproductive System connects-toCortisol connects-toHepatocyte connects-toThyroid connects-toIl 17A connects-toSmall Intestine connects-toMds connects-toIfn Gamma connects-toStat1 connects-toAll connects-toNf Kb connects-toStat3 connects-toSepsis connects-toAspergillus Fumigatus connects-toPneumocystis Jirovecii connects-toCkd connects-toWound Healing connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toDigestive System connects-toRespiratory System connects-toNervous System connects-toEndocrine System connects-toRenal System connects-toLymphatic System connects-toCardiovascular System connects-toVaricella Zoster Virus connects-toCorticosteroids connects-toHerpesvirus connects-toDietary Fiber connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toCortical Bone connects-toAplastic Anemia connects-toHepatic Lobule connects-toGerminal Center connects-toAlveolus connects-toDlbcl connects-toMyelofibrosis connects-toCovid 19 Disease connects-toThrombotic Thrombocytopenic Purpura connects-toDermatomyositis connects-toTgf Beta connects-toIl 1B connects-toNlrp3 Inflammasome connects-toMtor connects-toTlr4 connects-toS100A8 A9 connects-toBtk connects-toCcl2 connects-toCaspase 3 connects-toIl 33 connects-toBaff connects-toPeriostin connects-toNotch connects-toAkt connects-toIl 12 connects-toCgas Sting connects-toPd 1 connects-toPdgf connects-toErk1 2 connects-toSmad4 connects-toGalectin 3 connects-toPik3Ca connects-toEzh2 connects-toCxcl12 connects-toFoxo connects-toHif 1Alpha connects-toCdk4 6 connects-toGsk 3B connects-toSrc Kinase connects-toDnmt3A connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toComplement C3 connects-toAdenosine connects-toCd20 connects-toArid1A connects-toOsteopontin connects-toType I Interferon connects-toCtla 4 connects-toSecretory Iga connects-toBcl 2 connects-toCollagen connects-toIl 13 connects-toHemoglobin connects-toProstaglandins connects-toIl 4 connects-toXanthine Oxidase connects-toIron connects-toHepcidin connects-toNitric Oxide connects-toVegf connects-toComplement C5 connects-toIl 5 connects-toLiver connects-toT Helper Cell connects-toSystemic Sclerosis connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toC5Ar1 connects-toMast Cell connects-toNeutrophil connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toZinc connects-toSodium connects-toCopper connects-toCalcium connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toCarbon connects-toHydrogen connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine