Atlas One · Host Biology · Scale 07 — System

Atypical HUS

Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (MAHA + thrombocytopenia + AKI); Factor H mutations are most common (20-30%); uncontrolled alternative pathway at renal endothelium → microthrombi. Eculizumab is standard of care.

Also known as: aHUS, atypical HUS, atypical hemolytic uremic syndrome, complement-mediated TMA, CFH-HUS, HUS, thrombotic microangiopathy complement

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ahus

Atypical HUS

Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (MAHA + thrombocytopenia + AKI); Factor H mutations are most common (20-30%); uncontrolled alternative pathway at renal endothelium → microthrombi. Eculizumab is standard of care.

Entry Metadata

FieldValue
IDahus
NameAtypical HUS
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toFactor H connects-toComplement C3 connects-toComplement C5 connects-toCkd connects-toAdamts13 connects-toThrombotic Thrombocytopenic Purpura connects-toKidney connects-toEndothelial Cell connects-toEscherichia Coli connects-toGvhd connects-toPnh connects-toPlatelet connects-toErythrocyte connects-toDisseminated Intravascular Coagulation connects-toSystemic Lupus Erythematosus connects-toHeparin Induced Thrombocytopenia connects-toImmune Thrombocytopenia connects-toMalaria connects-toGlomerulus connects-toVon Willebrand Factor connects-toPodocyte connects-toPlacenta connects-toHypertension connects-toBrain connects-toC5Ar1 connects-toThrombin connects-toNeutrophil connects-toHemoglobin connects-toPotassium connects-toMacrophage connects-toHeart connects-toOxygen connects-toPancreas connects-toPhoton connects-toFibrosis connects-toLarge Intestine connects-toElectron connects-toLung connects-toEye connects-toNeuron connects-toAntibody connects-toLiver connects-toReproductive System connects-toSmooth Muscle Cell connects-toStroke connects-toStreptococcus Pneumoniae connects-toVegf connects-toSystemic Sclerosis connects-toAntiphospholipid Syndrome connects-toNervous System connects-toIl 6 connects-toNf Kb connects-toCardiomyocyte connects-toSepsis connects-toVenous Thromboembolism connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toNeisseria Meningitidis connects-toHeart Failure connects-toPulmonary Arterial Hypertension connects-toDigestive System connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toImmune System connects-toCardiovascular System connects-toEndocrine System connects-toRenal System connects-toRespiratory System connects-toNeisseria Meningitidis connects-toInfluenza A connects-toHiv 1 connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toArterial Wall connects-toMyocardium connects-toInherited Thrombophilia connects-toCovid 19 Disease connects-toAlveolus connects-toMyasthenia Gravis connects-toIga Nephropathy connects-toSkin connects-toIntestinal Epithelium connects-toPancreatic Cancer connects-toCardiac Conduction System connects-toNitric Oxide connects-toEndothelin 1 connects-toAngiotensin Ii connects-toPf4 connects-toS100A8 A9 connects-toTlr4 connects-toProtein C connects-toAngiopoietin connects-toCcl2 connects-toRage connects-toErythropoietin connects-toCaspase 3 connects-toHif 1Alpha connects-toTnf Alpha connects-toNlrp3 Inflammasome connects-toThrombopoietin connects-toSerotonin connects-toMyd88 connects-toAkt connects-toErk1 2 connects-toFibrinogen connects-toGalectin 3 connects-toCgas Sting connects-toStat3 connects-toJak1 2 connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toMtor connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toPerforin connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toImmunoglobulin G connects-toTroponin Complex connects-toCalcium connects-toEstrogen connects-toBradykinin connects-toXanthine Oxidase connects-toIl 10 connects-toAldosterone connects-toIron connects-toProstaglandins connects-toRenin connects-toZinc connects-toHepcidin connects-toIron connects-toMagnesium connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 4 connects-toIl 13 connects-toIl 5 connects-toC1 Esterase Inhibitor connects-toT Helper Cell connects-toIge connects-toOsteopontin connects-toTransferrin connects-toT Cytotoxic Cell connects-toTslp connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toSelenium connects-toVasopressin connects-toIodine connects-toSodium connects-toCopper connects-toPhosphorus connects-toNitrogen connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toTgf Beta connects-toPd 1 connects-toGlp 1 connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toMyostatin