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ahus
Atypical HUS
Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (MAHA + thrombocytopenia + AKI); Factor H mutations are most common (20-30%); uncontrolled alternative pathway at renal endothelium → microthrombi. Eculizumab is standard of care.
Entry Metadata
| Field | Value |
|---|---|
| ID | ahus |
| Name | Atypical HUS |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toFactor H
connects-toComplement C3
connects-toComplement C5
connects-toCkd
connects-toAdamts13
connects-toThrombotic Thrombocytopenic Purpura
connects-toKidney
connects-toEndothelial Cell
connects-toEscherichia Coli
connects-toGvhd
connects-toPnh
connects-toPlatelet
connects-toErythrocyte
connects-toDisseminated Intravascular Coagulation
connects-toSystemic Lupus Erythematosus
connects-toHeparin Induced Thrombocytopenia
connects-toImmune Thrombocytopenia
connects-toMalaria
connects-toGlomerulus
connects-toVon Willebrand Factor
connects-toPodocyte
connects-toPlacenta
connects-toHypertension
connects-toBrain
connects-toC5Ar1
connects-toThrombin
connects-toNeutrophil
connects-toHemoglobin
connects-toPotassium
connects-toMacrophage
connects-toHeart
connects-toOxygen
connects-toPancreas
connects-toPhoton
connects-toFibrosis
connects-toLarge Intestine
connects-toElectron
connects-toLung
connects-toEye
connects-toNeuron
connects-toAntibody
connects-toLiver
connects-toReproductive System
connects-toSmooth Muscle Cell
connects-toStroke
connects-toStreptococcus Pneumoniae
connects-toVegf
connects-toSystemic Sclerosis
connects-toAntiphospholipid Syndrome
connects-toNervous System
connects-toIl 6
connects-toNf Kb
connects-toCardiomyocyte
connects-toSepsis
connects-toVenous Thromboembolism
connects-toAnemia Of Chronic Disease
connects-toMajor Depressive Disorder
connects-toNeisseria Meningitidis
connects-toHeart Failure
connects-toPulmonary Arterial Hypertension
connects-toDigestive System
connects-toIntegumentary System
connects-toGeneralized Anxiety Disorder
connects-toImmune System
connects-toCardiovascular System
connects-toEndocrine System
connects-toRenal System
connects-toRespiratory System
connects-toNeisseria Meningitidis
connects-toInfluenza A
connects-toHiv 1
connects-toCancer Chemotherapy
connects-toTargeted Therapy
connects-toArterial Wall
connects-toMyocardium
connects-toInherited Thrombophilia
connects-toCovid 19 Disease
connects-toAlveolus
connects-toMyasthenia Gravis
connects-toIga Nephropathy
connects-toSkin
connects-toIntestinal Epithelium
connects-toPancreatic Cancer
connects-toCardiac Conduction System
connects-toNitric Oxide
connects-toEndothelin 1
connects-toAngiotensin Ii
connects-toPf4
connects-toS100A8 A9
connects-toTlr4
connects-toProtein C
connects-toAngiopoietin
connects-toCcl2
connects-toRage
connects-toErythropoietin
connects-toCaspase 3
connects-toHif 1Alpha
connects-toTnf Alpha
connects-toNlrp3 Inflammasome
connects-toThrombopoietin
connects-toSerotonin
connects-toMyd88
connects-toAkt
connects-toErk1 2
connects-toFibrinogen
connects-toGalectin 3
connects-toCgas Sting
connects-toStat3
connects-toJak1 2
connects-toStat1
connects-toFoxo
connects-toGsk 3B
connects-toMtor
connects-toPik3Ca
connects-toSrc Kinase
connects-toAmpk
connects-toPerforin
connects-toAutophagy
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 1B
connects-toIl 33
connects-toImmunoglobulin G
connects-toTroponin Complex
connects-toCalcium
connects-toEstrogen
connects-toBradykinin
connects-toXanthine Oxidase
connects-toIl 10
connects-toAldosterone
connects-toIron
connects-toProstaglandins
connects-toRenin
connects-toZinc
connects-toHepcidin
connects-toIron
connects-toMagnesium
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 4
connects-toIl 13
connects-toIl 5
connects-toC1 Esterase Inhibitor
connects-toT Helper Cell
connects-toIge
connects-toOsteopontin
connects-toTransferrin
connects-toT Cytotoxic Cell
connects-toTslp
connects-toHistamine
connects-toPeriostin
connects-toMelatonin
connects-toProlactin
connects-toOxytocin
connects-toTestosterone
connects-toSelenium
connects-toVasopressin
connects-toIodine
connects-toSodium
connects-toCopper
connects-toPhosphorus
connects-toNitrogen
connects-toChloride
connects-toSulfur
connects-toCarbon
connects-toHydrogen
connects-toTgf Beta
connects-toPd 1
connects-toGlp 1
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toFgfr
connects-toEpinephrine
connects-toMyostatin
Sources
- Fakhouri F, Zuber J, Frémeaux-Bacchi V, Loirat C. Haemolytic uraemic syndrome. Lancet. 2017;390(10095):681-696. · PubMed 28242109
- Legendre CM, Licht C, Muus P, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013;368(23):2169-2181. · PubMed 23738544
- Goodship TH, Cook HT, Fakhouri F, et al. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a 'Kidney Disease: Improving Global Outcomes' (KDIGO) Controversies Conference. Kidney Int. 2017;91(3):539-551. · PubMed 28062089