Atlas One · Host Biology · Scale 07 — System

Heparin-Induced Thrombocytopenia

Heparin-induced thrombocytopenia (HIT type 2) is an immune thrombocytopenia from anti-PF4/heparin IgG; platelet activation → paradoxical thrombosis. Stop heparin; switch to argatroban/bivalirudin/fondaparinux; avoid warfarin initially. 4T score guides clinical probability.

Also known as: HIT, heparin-induced thrombocytopenia, HIT type 2, HITT, heparin thrombocytopenia, anti-PF4 antibody, PF4-heparin antibody, VITT

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
heparin-induced-thrombocytopenia

Heparin-Induced Thrombocytopenia

Heparin-induced thrombocytopenia (HIT type 2) is an immune thrombocytopenia from anti-PF4/heparin IgG; platelet activation → paradoxical thrombosis. Stop heparin; switch to argatroban/bivalirudin/fondaparinux; avoid warfarin initially. 4T score guides clinical probability.

Entry Metadata

FieldValue
IDheparin-induced-thrombocytopenia
NameHeparin-Induced Thrombocytopenia
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPf4 connects-toPlatelet connects-toThrombin connects-toVenous Thromboembolism connects-toAntithrombin connects-toImmunoglobulin G connects-toEndothelial Cell connects-toInherited Thrombophilia connects-toPnh connects-toAntiphospholipid Syndrome connects-toStroke connects-toImmune Thrombocytopenia connects-toDisseminated Intravascular Coagulation connects-toCovid 19 Disease connects-toThrombotic Thrombocytopenic Purpura connects-toComplement C3 connects-toCardiovascular System connects-toMacrophage connects-toComplement C5 connects-toLung connects-toB Cell connects-toSpleen connects-toNeutrophil connects-toSerotonin connects-toSkin connects-toT Helper Cell connects-toFibrinogen connects-toCalcium connects-toDendritic Cell connects-toBrain connects-toAdrenal Gland connects-toOxygen connects-toPhoton connects-toHeart connects-toVon Willebrand Factor connects-toBone Marrow connects-toKidney connects-toElectron connects-toAntibody connects-toLiver connects-toNeuron connects-toSmooth Muscle Cell connects-toEye connects-toReproductive System connects-toCardiomyocyte connects-toCkd connects-toAtherosclerosis connects-toMast Cell connects-toFcrn connects-toSepsis connects-toPlasma Cell connects-toNf Kb connects-toPulmonary Arterial Hypertension connects-toHeart Failure connects-toAnemia Of Chronic Disease connects-toPolycythemia Vera connects-toWound Healing connects-toPtsd connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toImmune System connects-toRespiratory System connects-toDigestive System connects-toNervous System connects-toRenal System connects-toMusculoskeletal System connects-toWarfarin connects-toAhus connects-toStaphylococcus Aureus connects-toArterial Wall connects-toMyocardium connects-toEssential Thrombocythemia connects-toHemophilia A connects-toGlomerulus connects-toAlveolus connects-toHepatic Lobule connects-toGerminal Center connects-toPancreatic Cancer connects-toProtein C connects-toPeripheral Nerve connects-toMyelofibrosis connects-toAkt connects-toNlrp3 Inflammasome connects-toTnf Alpha connects-toPdgf connects-toFibronectin connects-toCxcl12 connects-toProstaglandins connects-toCcl2 connects-toNitric Oxide connects-toS100A8 A9 connects-toBaff connects-toTlr4 connects-toHif 1Alpha connects-toIl 6 connects-toCaspase 3 connects-toSrc Kinase connects-toThrombopoietin connects-toC5Ar1 connects-toMyd88 connects-toErk1 2 connects-toPik3Ca connects-toGalectin 3 connects-toStat3 connects-toCgas Sting connects-toJak1 2 connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toMtor connects-toEndothelin 1 connects-toCcr5 connects-toAutophagy connects-toAmpk connects-toDnmt3A connects-toIl 1B connects-toCd20 connects-toIl 33 connects-toIl 17A connects-toCalcineurin connects-toMhc Class Ii connects-toCtla 4 connects-toVegf connects-toTroponin Complex connects-toIl 2 connects-toIl 4 connects-toIl 10 connects-toIl 13 connects-toXanthine Oxidase connects-toAdenosine connects-toHistamine connects-toZinc connects-toRegulatory T Cell connects-toPd 1 connects-toType I Interferon connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNatural Killer Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toFactor H connects-toBradykinin connects-toT Cytotoxic Cell connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toTransferrin connects-toTslp connects-toErythropoietin connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPhosphorus connects-toPotassium connects-toIron connects-toChloride connects-toCarbon connects-toNitrogen connects-toSulfur connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine