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heparin-induced-thrombocytopenia
Heparin-Induced Thrombocytopenia
Heparin-induced thrombocytopenia (HIT type 2) is an immune thrombocytopenia from anti-PF4/heparin IgG; platelet activation → paradoxical thrombosis. Stop heparin; switch to argatroban/bivalirudin/fondaparinux; avoid warfarin initially. 4T score guides clinical probability.
Entry Metadata
| Field | Value |
|---|---|
| ID | heparin-induced-thrombocytopenia |
| Name | Heparin-Induced Thrombocytopenia |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):311S-337S. · PubMed 15383477
- Greinacher A, Thiele T, Warkentin TE, et al. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med. 2021;384(22):2092-2101. · PubMed 33835769
- Linkins LA, Dans AL, Moores LK, et al. Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e495S-e530S. · PubMed 22315270