Atlas One · Host Biology · Scale 07 — System

Hemophilia A

Hemophilia A is X-linked FVIII deficiency (F8 gene; Xq28); severe <1 IU/dL → joint/muscle hemorrhage. Emicizumab (bispecific FIXa/FX mAb; HAVEN-3: ABR 0.3 vs 22.9; FDA 2017) replaced prophylactic FVIII as standard of care in inhibitor and non-inhibitor severe HA.

Also known as: hemophilia A, HA, factor VIII deficiency, FVIII deficiency, hemophilia A with inhibitors, haemophilia A, congenital FVIII deficiency

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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hemophilia-a

Hemophilia A

Hemophilia A is X-linked FVIII deficiency (F8 gene; Xq28); severe <1 IU/dL → joint/muscle hemorrhage. Emicizumab (bispecific FIXa/FX mAb; HAVEN-3: ABR 0.3 vs 22.9; FDA 2017) replaced prophylactic FVIII as standard of care in inhibitor and non-inhibitor severe HA.

Entry Metadata

FieldValue
IDhemophilia-a
NameHemophilia A
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toVon Willebrand Factor connects-toImmunoglobulin G connects-toThrombin connects-toProtein C connects-toVenous Thromboembolism connects-toHepatocyte connects-toAntithrombin connects-toInherited Thrombophilia connects-toMusculoskeletal System connects-toEndothelial Cell connects-toPlatelet

Sources