Atlas One · Host Biology · Scale 07 — System

Hemophilia A

Hemophilia A is X-linked FVIII deficiency (F8 gene; Xq28); severe <1 IU/dL → joint/muscle hemorrhage. Emicizumab (bispecific FIXa/FX mAb; HAVEN-3: ABR 0.3 vs 22.9; FDA 2017) replaced prophylactic FVIII as standard of care in inhibitor and non-inhibitor severe HA.

Also known as: hemophilia A, HA, factor VIII deficiency, FVIII deficiency, hemophilia A with inhibitors, haemophilia A, congenital FVIII deficiency

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hemophilia-a

Hemophilia A

Hemophilia A is X-linked FVIII deficiency (F8 gene; Xq28); severe <1 IU/dL → joint/muscle hemorrhage. Emicizumab (bispecific FIXa/FX mAb; HAVEN-3: ABR 0.3 vs 22.9; FDA 2017) replaced prophylactic FVIII as standard of care in inhibitor and non-inhibitor severe HA.

Entry Metadata

FieldValue
IDhemophilia-a
NameHemophilia A
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toVon Willebrand Factor connects-toImmunoglobulin G connects-toThrombin connects-toProtein C connects-toVenous Thromboembolism connects-toHepatocyte connects-toAntithrombin connects-toInherited Thrombophilia connects-toMusculoskeletal System connects-toEndothelial Cell connects-toPlatelet connects-toDisseminated Intravascular Coagulation connects-toImmune Thrombocytopenia connects-toThrombotic Thrombocytopenic Purpura connects-toLiver connects-toStroke connects-toAntiphospholipid Syndrome connects-toFibrinogen connects-toBrain connects-toHepatitis C connects-toReproductive System connects-toImmune System connects-toErythrocyte connects-toCalcium connects-toT Helper Cell connects-toMacrophage connects-toCollagen connects-toRegulatory T Cell connects-toB Cell connects-toIron connects-toKidney connects-toLarge Intestine connects-toPhoton connects-toSkin connects-toBone Marrow connects-toHiv Aids connects-toElectron connects-toEye connects-toNeuron connects-toOsteoblast connects-toSmooth Muscle Cell connects-toAntibody connects-toPeripheral Nerve connects-toHepatitis B connects-toOsteoclast connects-toOsteoporosis connects-toDendritic Cell connects-toFibroblast connects-toT Cytotoxic Cell connects-toIron Deficiency Anemia connects-toNf Kb connects-toAnemia Of Chronic Disease connects-toSepsis connects-toOpioid Use Disorder connects-toMajor Depressive Disorder connects-toHeart Failure connects-toNeuropathic Pain connects-toCkd connects-toHypertension connects-toWound Healing connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toRenal System connects-toIntegumentary System connects-toRespiratory System connects-toCardiovascular System connects-toIbuprofen connects-toTargeted Therapy connects-toLymphatic System connects-toPrion Protein connects-toCortical Bone connects-toHepatic Lobule connects-toSickle Cell Disease connects-toHeparin Induced Thrombocytopenia connects-toRheumatoid Arthritis connects-toDlbcl connects-toHcc connects-toGerminal Center connects-toArterial Wall connects-toBreast Cancer connects-toGlomerulus connects-toCovid 19 Disease connects-toRankl connects-toTnf Alpha connects-toVegf connects-toIl 1B connects-toPdgf connects-toTgf Beta connects-toCcl2 connects-toHif 1Alpha connects-toTlr4 connects-toAngiopoietin connects-toCaspase 3 connects-toIl 6 connects-toIl 10 connects-toNlrp3 Inflammasome connects-toFerroportin connects-toS100A8 A9 connects-toFcrn connects-toCtla 4 connects-toMyd88 connects-toJak1 2 connects-toErk1 2 connects-toGalectin 3 connects-toSmad4 connects-toStat3 connects-toFoxo connects-toStat1 connects-toCgas Sting connects-toAkt connects-toGsk 3B connects-toPerforin connects-toPik3Ca connects-toMtor connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toComplement C3 connects-toIl 33 connects-toCalcineurin connects-toType I Interferon connects-toHemoglobin connects-toMu Opioid Receptor connects-toMhc Class Ii connects-toIl 2 connects-toIl 4 connects-toProstaglandins connects-toXanthine Oxidase connects-toIl 13 connects-toCalcium connects-toIl 17A connects-toNitric Oxide connects-toPd 1 connects-toRegulatory T Cell connects-toBaff connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toMast Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toZinc connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toCarbon connects-toCopper connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr

Sources