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prion-protein
Prion Protein
Prion protein: PrPC (normal, α-helical) vs. PrPSc (pathological, β-sheet-rich). PrPSc propagates by templating PrPC misfolding; resists protease, heat, formalin. Causes CJD, kuru, FFI, GSS. 100% fatality. No nucleic acid genome; pure protein pathogen.
Entry Metadata
| Field | Value |
|---|---|
| ID | prion-protein |
| Name | Prion Protein |
| Status | draft |
| Last reviewed | 2026-06-05 |
| Class | 05-prions |
Cross-Atlas Connections
Sources
- Prusiner SB. Nobel lecture: prions. Proc Natl Acad Sci USA. 1998;95(23):13363-83. · PubMed 9811807
- Collinge J. Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci. 2001;24:519-50. · PubMed 11283320
- Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev. 2009;89(4):1105-52. · PubMed 19789378