Atlas One · Host Biology · Scale 07 — System

Inherited Thrombophilia

Inherited thrombophilias are genetic risk factors for VTE; Factor V Leiden R506Q (5% Europeans; APC resistance) and prothrombin G20210A are most common; protein C/S and antithrombin deficiencies are rarer but higher-risk. Duration of anticoagulation is the main clinical impact.

Also known as: inherited thrombophilia, hereditary thrombophilia, thrombophilia, factor V Leiden, FVL, prothrombin G20210A, APC resistance, thrombophilic disorder

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
inherited-thrombophilia

Inherited Thrombophilia

Inherited thrombophilias are genetic risk factors for VTE; Factor V Leiden R506Q (5% Europeans; APC resistance) and prothrombin G20210A are most common; protein C/S and antithrombin deficiencies are rarer but higher-risk. Duration of anticoagulation is the main clinical impact.

Entry Metadata

FieldValue
IDinherited-thrombophilia
NameInherited Thrombophilia
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toProtein C connects-toThrombin connects-toVenous Thromboembolism connects-toAntiphospholipid Syndrome connects-toAntithrombin connects-toHemophilia A connects-toLiver connects-toStroke connects-toEndothelial Cell connects-toHeparin Induced Thrombocytopenia connects-toPnh connects-toPolycythemia Vera connects-toDisseminated Intravascular Coagulation connects-toAtherosclerosis connects-toMyeloproliferative Neoplasms connects-toPulmonary Arterial Hypertension connects-toPlatelet connects-toEstrogen connects-toLung connects-toBrain connects-toPlacenta connects-toFibrinogen connects-toSickle Cell Disease connects-toCalcium connects-toHepatocyte connects-toObesity connects-toVon Willebrand Factor connects-toNeutrophil connects-toOxygen connects-toKidney connects-toSpleen connects-toAdrenal Gland connects-toPhoton connects-toErythrocyte connects-toBone Marrow connects-toElectron connects-toHeart connects-toFibrosis connects-toSkin connects-toEye connects-toNeuron connects-toAntibody connects-toReproductive System connects-toLarge Intestine connects-toComplement C5 connects-toMacrophage connects-toCkd connects-toPancreatic Cancer connects-toCovid 19 Disease connects-toSepsis connects-toNf Kb connects-toHcc connects-toEssential Thrombocythemia connects-toHeart Failure connects-toOvarian Cancer connects-toGastric Cancer connects-toWound Healing connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toDigestive System connects-toNervous System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toIntegumentary System connects-toRenal System connects-toCardiovascular System connects-toEndocrine System connects-toLymphatic System connects-toWarfarin connects-toImmune System connects-toMusculoskeletal System connects-toAspirin connects-toHepatic Lobule connects-toStatins connects-toAlveolus connects-toGlomerulus connects-toAhus connects-toArterial Wall connects-toInflammatory Bowel Disease connects-toGlioblastoma connects-toMyocardium connects-toThalassemia connects-toMyelofibrosis connects-toIl 6 connects-toNlrp3 Inflammasome connects-toEndothelin 1 connects-toNitric Oxide connects-toPf4 connects-toFibronectin connects-toHif 1Alpha connects-toCcl2 connects-toProstaglandins connects-toS100A8 A9 connects-toTlr4 connects-toComplement C3 connects-toAngiopoietin connects-toIl 1B connects-toTnf Alpha connects-toC5Ar1 connects-toSerotonin connects-toThrombopoietin connects-toAkt connects-toErk1 2 connects-toVegf connects-toGalectin 3 connects-toCgas Sting connects-toPik3Ca connects-toJak1 2 connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toStat3 connects-toMtor connects-toSrc Kinase connects-toAmpk connects-toCcr5 connects-toAutophagy connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toAdenosine connects-toTestosterone connects-toHemoglobin connects-toLeptin connects-toProgesterone connects-toTroponin Complex connects-toInsulin connects-toXanthine Oxidase connects-toIl 10 connects-toGlp 1 connects-toIl 4 connects-toCholesterol connects-toZinc connects-toImmunoglobulin G connects-toType I Interferon connects-toAdiponectin connects-toResistin connects-toLung connects-toLiver connects-toNatural Killer Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 13 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toFactor H connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toIron connects-toPhosphorus connects-toChloride connects-toCarbon connects-toNitrogen connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf

Sources