Atlas One · Host Biology · Scale 03 — Molecular

Thrombin

Thrombin (Factor IIa) is the central coagulation serine protease cleaving fibrinogen to fibrin, activating platelets via PAR-1, and amplifying the clotting cascade; arterial thrombi cause ischemic stroke and MI; dabigatran (direct thrombin inhibitor) prevents thrombotic events.

Also known as: thrombin, Factor IIa, prothrombin, F2, serine protease, coagulation cascade, dabigatran, PAR-1, direct thrombin inhibitor, DTI, fibrin clot, anticoagulant

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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thrombin

Thrombin

Thrombin (Factor IIa) is the central coagulation serine protease cleaving fibrinogen to fibrin, activating platelets via PAR-1, and amplifying the clotting cascade; arterial thrombi cause ischemic stroke and MI; dabigatran (direct thrombin inhibitor) prevents thrombotic events.

Entry Metadata

FieldValue
IDthrombin
NameThrombin
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toStroke connects-toCardiovascular System connects-toNlrp3 Inflammasome connects-toFibrinogen connects-toVenous Thromboembolism connects-toDisseminated Intravascular Coagulation connects-toC1 Esterase Inhibitor connects-toProtein C connects-toInherited Thrombophilia connects-toHeparin Induced Thrombocytopenia connects-toAntithrombin connects-toHemophilia A connects-toHereditary Angioedema

Sources