Atlas One · Host Biology · Scale 03 — Molecular

Antithrombin

Antithrombin (SERPINC1; AT-III; chr1q25.1) is the primary serine protease inhibitor of thrombin and FXa; heparin accelerates AT inhibition ~1000×; AT deficiency (rare; 1:5000) is the most thrombogenic inherited thrombophilia; consumed in DIC; bivalirudin bypasses AT.

Also known as: antithrombin, AT-III, antithrombin III, SERPINC1, heparin cofactor I, antithrombin-III

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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antithrombin

Antithrombin

Antithrombin (SERPINC1; AT-III; chr1q25.1) is the primary serine protease inhibitor of thrombin and FXa; heparin accelerates AT inhibition ~1000×; AT deficiency (rare; 1:5000) is the most thrombogenic inherited thrombophilia; consumed in DIC; bivalirudin bypasses AT.

Entry Metadata

FieldValue
IDantithrombin
NameAntithrombin
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toThrombin connects-toVenous Thromboembolism connects-toInherited Thrombophilia connects-toDisseminated Intravascular Coagulation connects-toHeparin Induced Thrombocytopenia

Sources