Atlas One · Host Biology · Scale 07 — System

Disseminated Intravascular Coagulation

DIC is a syndrome of microvascular thrombosis and consumption coagulopathy from systemic thrombin activation; sepsis, obstetric emergencies, and malignancy are top triggers. ISTH score ≥5 = overt DIC. Treatment targets underlying cause; FFP + cryoprecipitate for bleeding.

Also known as: DIC, disseminated intravascular coagulation, consumptive coagulopathy, defibrination syndrome, DIC coagulopathy, overt DIC, non-overt DIC, microangiopathic coagulation

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
disseminated-intravascular-coagulation

Disseminated Intravascular Coagulation

DIC is a syndrome of microvascular thrombosis and consumption coagulopathy from systemic thrombin activation; sepsis, obstetric emergencies, and malignancy are top triggers. ISTH score ≥5 = overt DIC. Treatment targets underlying cause; FFP + cryoprecipitate for bleeding.

Entry Metadata

FieldValue
IDdisseminated-intravascular-coagulation
NameDisseminated Intravascular Coagulation
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toFibrinogen connects-toThrombin connects-toNlrp3 Inflammasome connects-toAntithrombin connects-toPlatelet connects-toProtein C connects-toSepsis connects-toEssential Thrombocythemia connects-toCytokine Storm connects-toLiver connects-toEndothelial Cell connects-toAml connects-toPlacenta connects-toThrombotic Thrombocytopenic Purpura connects-toPancreatic Cancer connects-toErythrocyte connects-toKidney connects-toVon Willebrand Factor connects-toImmune Thrombocytopenia connects-toNeutrophil connects-toLung connects-toMalaria connects-toComplement C3 connects-toMacrophage connects-toBrain connects-toCalcium connects-toAdrenal Gland connects-toHemoglobin connects-toTnf Alpha connects-toHeart connects-toOxygen connects-toHydrogen connects-toSkin connects-toBone Marrow connects-toPhoton connects-toGlomerulus connects-toComplement C5 connects-toElectron connects-toLarge Intestine connects-toSpleen connects-toNeuron connects-toReproductive System connects-toEye connects-toProstate Cancer connects-toPancreas connects-toStroke connects-toNf Kb connects-toAll connects-toSmall Intestine connects-toNeisseria Meningitidis connects-toBradykinin connects-toDengue Fever connects-toCkd connects-toArds connects-toVenous Thromboembolism connects-toHeart Failure connects-toPnh connects-toMajor Depressive Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toPtsd connects-toIntegumentary System connects-toRespiratory System connects-toDigestive System connects-toRenal System connects-toNervous System connects-toEndocrine System connects-toCardiovascular System connects-toImmune System connects-toMusculoskeletal System connects-toStaphylococcus Aureus connects-toAhus connects-toHeparin Induced Thrombocytopenia connects-toCancer Chemotherapy connects-toHepatic Lobule connects-toAntiphospholipid Syndrome connects-toAlveolus connects-toGastric Cancer connects-toMyocardium connects-toNeisseria Meningitidis connects-toArterial Wall connects-toCovid 19 Disease connects-toEbola Virus connects-toStreptococcus Pyogenes connects-toIl 6 connects-toIl 1B connects-toNitric Oxide connects-toEndothelin 1 connects-toS100A8 A9 connects-toTlr4 connects-toPf4 connects-toCcl2 connects-toRage connects-toCgas Sting connects-toAdamts13 connects-toCaspase 3 connects-toXanthine Oxidase connects-toAngiopoietin connects-toC5Ar1 connects-toThrombopoietin connects-toMyd88 connects-toJak1 2 connects-toVegf connects-toErk1 2 connects-toAkt connects-toGalectin 3 connects-toStat3 connects-toPik3Ca connects-toStat1 connects-toFoxo connects-toHif 1Alpha connects-toSmad4 connects-toGsk 3B connects-toMtor connects-toPerforin connects-toSrc Kinase connects-toAmpk connects-toCcr5 connects-toAutophagy connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toProton connects-toTroponin Complex connects-toOxygen connects-toIl 10 connects-toHepcidin connects-toAdrenomedullin connects-toProstaglandins connects-toSerotonin connects-toIron connects-toZinc connects-toResistin connects-toHistamine connects-toLeptin connects-toAdiponectin connects-toType I Interferon connects-toNeutrophil connects-toAml connects-toKidney connects-toIfn Gamma connects-toIl 12 connects-toIl 4 connects-toIl 13 connects-toIl 5 connects-toIl 23 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toOsteopontin connects-toMast Cell connects-toT Helper Cell connects-toTslp connects-toErythropoietin connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toIl 2 connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toBdnf connects-toFgfr

Sources