Atlas One · Host Biology · Scale 03 — Molecular

ARID1A

ARID1A (BAF250A) is the most mutated SWI/SNF gene; LOF disrupts cBAF → EZH2 dependency; most frequent in ovarian clear cell (~50%), uterine endometrioid (~40%), gastric cancer; ARID1A LOF suppresses MLH1; co-mutation with PIK3CA defines ovarian clear cell carcinoma.

Also known as: ARID1A, BAF250A, ARID1A mutation, SWI/SNF ARID1A, ARID1A ovarian, ARID1A endometrial, ARID1A gastric, BAF complex ARID1A, ARID1A LOF cancer, OCCC ARID1A

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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arid1a

ARID1A

ARID1A (BAF250A) is the most mutated SWI/SNF gene; LOF disrupts cBAF → EZH2 dependency; most frequent in ovarian clear cell (~50%), uterine endometrioid (~40%), gastric cancer; ARID1A LOF suppresses MLH1; co-mutation with PIK3CA defines ovarian clear cell carcinoma.

Entry Metadata

FieldValue
IDarid1a
NameARID1A
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toEzh2 connects-toSmarcb1 connects-toPik3Ca connects-toMlh1 connects-toOvarian Clear Cell Carcinoma connects-toP53 connects-toRad51

Sources