Atlas One · Host Biology · Scale 03 — Molecular

SMARCB1

SMARCB1 (INI1/BAF47) is a core SWI/SNF BAF complex subunit; biallelic LOF in ~100% AT/RT, rhabdoid tumors, and epithelioid sarcoma; SMARCB1 loss → PRC2/EZH2-mediated H3K27me3 at tumor suppressor loci; tazemetostat (EZH2 inhibitor) FDA-approved for epithelioid sarcoma.

Also known as: SMARCB1, INI1, BAF47, SNF5, hSNF5, SMARCB1 rhabdoid, INI1 loss, rhabdoid tumor predisposition, RTPS1, SWI/SNF tumor suppressor

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
smarcb1

SMARCB1

SMARCB1 (INI1/BAF47) is a core SWI/SNF BAF complex subunit; biallelic LOF in ~100% AT/RT, rhabdoid tumors, and epithelioid sarcoma; SMARCB1 loss → PRC2/EZH2-mediated H3K27me3 at tumor suppressor loci; tazemetostat (EZH2 inhibitor) FDA-approved for epithelioid sarcoma.

Entry Metadata

FieldValue
IDsmarcb1
NameSMARCB1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toEzh2 connects-toRb1 connects-toCdkn2A connects-toMyc connects-toP53 connects-toArid1A connects-toNf2

Sources