Atlas One · Host Biology · Scale 03 — Molecular

NF2

NF2 (merlin) is a FERM-domain tumor suppressor; LOF → Hippo pathway loss → YAP/TAZ nuclear → TEAD-driven proliferation; biallelic NF2 LOF in ~50-60% meningioma and ~50% mesothelioma; germline NF2 syndrome — bilateral VS, meningiomas, ependymomas; mTOR inhibitors active in VS.

Also known as: NF2, merlin, schwannomin, NF2 tumor suppressor, NF2 syndrome, neurofibromatosis type 2, vestibular schwannoma, NF2 meningioma, NF2 mesothelioma, Hippo pathway NF2

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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nf2

NF2

NF2 (merlin) is a FERM-domain tumor suppressor; LOF → Hippo pathway loss → YAP/TAZ nuclear → TEAD-driven proliferation; biallelic NF2 LOF in ~50-60% meningioma and ~50% mesothelioma; germline NF2 syndrome — bilateral VS, meningiomas, ependymomas; mTOR inhibitors active in VS.

Entry Metadata

FieldValue
IDnf2
NameNF2
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMtor connects-toEgfr connects-toPten connects-toErk1 2

Sources