PIK3CA

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pik3ca

Catalytic subunit of PI3K; phosphorylates PIP2 to PIP3, activating AKT-mTOR. Gain-of-function mutations (H1047R, E545K) in 25-40% of breast and 15% of colorectal cancers. Alpelisib (PI3K-alpha inhibitor) approved for PIK3CA-mutant HR+/HER2- breast cancer.

Entry Metadata

Field	Value
ID	pik3ca
Name	PIK3CA
Status	draft
Last reviewed	2026-06-06
Atlas	01-human
Scale	03-molecular

Cross-Atlas Connections

connects-toMtor connects-toHer2 connects-toKras connects-toP53

Sources

Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004;304(5670):554. · PubMed 15016963
André F, Ciruelos E, Rubovszky G, et al. Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer. N Engl J Med. 2019;380(20):1929-1940. · PubMed 31091374
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7(8):606-619. · PubMed 16847462