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c5ar1
C5aR1
C5aR1 (CD88; C5AR1, chr19q13.3) is the high-affinity GPCR for complement fragment C5a; Gαi → IP3/DAG → Ca²⁺/ERK → neutrophil activation, ROS, NET formation. Avacopan (C5aR1 antagonist; FDA Oct 2021) enables steroid-sparing remission induction in ANCA vasculitis.
Entry Metadata
| Field | Value |
|---|---|
| ID | c5ar1 |
| Name | C5aR1 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Jayne DRW, Merkel PA, Schall TJ, Bekker P. Avacopan for the Treatment of ANCA-Associated Vasculitis. N Engl J Med. 2021;384(7):599-609. · PubMed 33596356
- Ward PA. Functions of C5a receptors. J Mol Med (Berl). 2009;87(4):375-378. · PubMed 19224192
- Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785-797. · PubMed 20720586