Atlas One · Host Biology · Scale 03 — Molecular

Complement C5

Complement C5 (C5, chr9q33.2) is cleaved by C5 convertase → C5a (potent anaphylatoxin) + C5b (MAC assembly initiator); eculizumab and ravulizumab (anti-C5 mAbs) block terminal complement → approved for PNH, aHUS, gMG, NMOSD, and HSCT-TMA.

Also known as: C5, complement component 5, C5a, C5b, C5b-9, MAC, terminal complement, anaphylatoxin

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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complement-c5

Complement C5

Complement C5 (C5, chr9q33.2) is cleaved by C5 convertase → C5a (potent anaphylatoxin) + C5b (MAC assembly initiator); eculizumab and ravulizumab (anti-C5 mAbs) block terminal complement → approved for PNH, aHUS, gMG, NMOSD, and HSCT-TMA.

Entry Metadata

FieldValue
IDcomplement-c5
NameComplement C5
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toPnh connects-toImmune System connects-toMyasthenia Gravis connects-toNmo connects-toAquaporin 4 connects-toC5Ar1 connects-toAnca Vasculitis connects-toBeta2 Glycoprotein 1 connects-toAntiphospholipid Syndrome connects-toAhus connects-toGuillain Barre

Sources