Atlas One · Host Biology · Scale 07 — System

Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune NMJ disease; AChR antibodies (85%) activate complement → AChR destruction → fatigable weakness; MuSK antibodies (6%) cause IgG4-mediated dysfunction. Pyridostigmine, steroids, thymectomy, eculizumab, and efgartigimod are treatments.

Also known as: MG, myasthenia gravis, generalised myasthenia gravis, gMG, AChR antibody, MuSK antibody, seronegative MG, myasthenic crisis, ocular MG, neuromuscular junction disease, fatigable weakness, ptosis, diplopia

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
myasthenia-gravis

Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune NMJ disease; AChR antibodies (85%) activate complement → AChR destruction → fatigable weakness; MuSK antibodies (6%) cause IgG4-mediated dysfunction. Pyridostigmine, steroids, thymectomy, eculizumab, and efgartigimod are treatments.

Entry Metadata

FieldValue
IDmyasthenia-gravis
NameMyasthenia Gravis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toAcetylcholine connects-toComplement C5 connects-toFcrn connects-toThymus connects-toB Cell connects-toSnare Complex connects-toMultiple Sclerosis connects-toImmunoglobulin G connects-toNeuron connects-toNeuromuscular Junction connects-toT Helper Cell connects-toCidp connects-toNmo connects-toPemphigus Vulgaris connects-toPlasma Cell connects-toMacrophage connects-toRheumatoid Arthritis connects-toEye connects-toCd20 connects-toImmune System connects-toNervous System connects-toLung connects-toThyroid connects-toRegulatory T Cell connects-toMhc Class Ii connects-toCalcium connects-toCardiomyocyte connects-toSodium connects-toIl 6 connects-toDendritic Cell connects-toOxygen connects-toBone Marrow connects-toHeart connects-toPhoton connects-toMagnesium connects-toPeripheral Nerve connects-toElectron connects-toPotassium connects-toAdrenal Gland connects-toAntibody connects-toComplement C3 connects-toSmooth Muscle Cell connects-toMusculoskeletal System connects-toReproductive System connects-toNeutrophil connects-toBaff connects-toSystemic Lupus Erythematosus connects-toSpleen connects-toSynapse connects-toGerminal Center connects-toIl 17A connects-toNf Kb connects-toSepsis connects-toVenous Thromboembolism connects-toOsteoporosis connects-toPneumocystis Jirovecii connects-toSjogrens Syndrome connects-toAspergillus Fumigatus connects-toType 2 Diabetes connects-toMajor Depressive Disorder connects-toRespiratory System connects-toDigestive System connects-toEndocrine System connects-toLymphatic System connects-toCardiovascular System connects-toIntegumentary System connects-toRenal System connects-toBeta Blockers connects-toStreptococcus Pneumoniae connects-toCorticosteroids connects-toCheckpoint Inhibitors connects-toType 1 Diabetes connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toSclc connects-toMyocardium connects-toGuillain Barre connects-toGvhd connects-toPnh connects-toDermatomyositis connects-toCovid 19 Disease connects-toAlveolus connects-toCardiac Conduction System connects-toAplastic Anemia connects-toIfn Gamma connects-toTnf Alpha connects-toNlrp3 Inflammasome connects-toCalcineurin connects-toIl 2 connects-toCcl2 connects-toBtk connects-toEstrogen connects-toRankl connects-toGlucocorticoid Receptor connects-toBcl 2 connects-toCalcium connects-toStat3 connects-toIl 10 connects-toTgf Beta connects-toJak1 2 connects-toIl 23 connects-toIl 12 connects-toAkt connects-toMtor connects-toErk1 2 connects-toGalectin 3 connects-toStat1 connects-toSmad4 connects-toFoxo connects-toS100A8 A9 connects-toCgas Sting connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 1B connects-toArid1A connects-toAdenosine connects-toCtla 4 connects-toPd 1 connects-toTroponin Complex connects-toIl 4 connects-toT Cytotoxic Cell connects-toProgesterone connects-toThyroid Hormones connects-toIl 13 connects-toXanthine Oxidase connects-toNitric Oxide connects-toProstaglandins connects-toZinc connects-toType I Interferon connects-toNatural Killer Cell connects-toLeptin connects-toAdiponectin connects-toResistin connects-toCortical Bone connects-toSystemic Sclerosis connects-toIl 5 connects-toIge connects-toMast Cell connects-toVitamin D connects-toSelenium connects-toC5Ar1 connects-toC1 Esterase Inhibitor connects-toFactor H connects-toOsteopontin connects-toPeriostin connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toCopper connects-toIron connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toVegf connects-toWnt Beta Catenin connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources