Atlas One · Host Biology · Scale 07 — System

Small Cell Lung Cancer

Small cell lung cancer is a high-grade neuroendocrine carcinoma with near-universal RB1 and TP53 loss; atezolizumab or durvalumab + carboplatin/etoposide is first-line for extensive stage; DLL3-targeting tarlatamab is approved for relapsed disease; 5-year OS <10%.

Also known as: SCLC, small cell lung cancer, small cell carcinoma, limited stage SCLC, extensive stage SCLC, oat cell carcinoma, SCLC-A, neuroendocrine lung cancer, lurbinectedin SCLC, tarlatamab SCLC

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
sclc

Small Cell Lung Cancer

Small cell lung cancer is a high-grade neuroendocrine carcinoma with near-universal RB1 and TP53 loss; atezolizumab or durvalumab + carboplatin/etoposide is first-line for extensive stage; DLL3-targeting tarlatamab is approved for relapsed disease; 5-year OS <10%.

Entry Metadata

FieldValue
IDsclc
NameSmall Cell Lung Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDll3 connects-toRb1 connects-toPd 1 connects-toP53 connects-toLung connects-toNsclc connects-toNeuroendocrine Tumors connects-toTuberculosis connects-toNeuron connects-toBrain connects-toPhoton connects-toRetinoblastoma connects-toMacrophage connects-toCarbon connects-toHnscc connects-toEsophageal Cancer connects-toMyc connects-toAdrenal Gland connects-toNervous System connects-toImmune System connects-toEndocrine System connects-toLiver connects-toT Cytotoxic Cell connects-toVasopressin connects-toActh connects-toCalcium connects-toNotch connects-toRegulatory T Cell connects-toSodium connects-toNeuromuscular Junction connects-toDendritic Cell connects-toPotassium connects-toEye connects-toBone Marrow connects-toElectron connects-toCortisol connects-toPeripheral Nerve connects-toNeutrophil connects-toMagnesium connects-toT Helper Cell connects-toAntibody connects-toErythrocyte connects-toSkin connects-toMycn connects-toVenous Thromboembolism connects-toPlatelet connects-toCtla 4 connects-toCopd connects-toEndothelial Cell connects-toStat3 connects-toNf Kb connects-toSepsis connects-toIl 6 connects-toAnemia Of Chronic Disease connects-toStroke connects-toCkd connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toStreptococcus Pneumoniae connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toDigestive System connects-toMusculoskeletal System connects-toLymphatic System connects-toCardiovascular System connects-toRenal System connects-toTargeted Therapy connects-toIntegumentary System connects-toReproductive System connects-toCancer Chemotherapy connects-toMyasthenia Gravis connects-toCheckpoint Inhibitors connects-toHippocampus connects-toHepatic Lobule connects-toNeuroblastoma connects-toAlveolus connects-toBladder Cancer connects-toGerminal Center connects-toEpilepsy connects-toAxonal Transport connects-toCardiac Conduction System connects-toYap1 connects-toEzh2 connects-toBcl 2 connects-toAkt connects-toCdk4 6 connects-toHif 1Alpha connects-toTert connects-toKit connects-toCgas Sting connects-toRad51 connects-toSstr2 connects-toAcetylcholine connects-toE2F1 connects-toCaspase 3 connects-toPik3Ca connects-toMtor connects-toVegf connects-toPerforin connects-toJak1 2 connects-toNfe2L2 connects-toMyd88 connects-toGalectin 3 connects-toTgf Beta connects-toErk1 2 connects-toStat1 connects-toSmad4 connects-toFoxo connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toMdm2 connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toMhc Class Ii connects-toIgf 1 connects-toCalcitonin connects-toIl 2 connects-toXanthine Oxidase connects-toHemoglobin connects-toProton connects-toIl 10 connects-toMu Opioid Receptor connects-toProstaglandins connects-toIl 4 connects-toIron connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toCortical Bone connects-toHepcidin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toNatural Killer Cell connects-toC5Ar1 connects-toComplement C3 connects-toComplement C5 connects-toB Cell connects-toTslp connects-toErythropoietin connects-toHistamine connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toProlactin connects-toSelenium connects-toIodine connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toNorepinephrine connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toGhrelin

Sources