Atlas One · Host Biology · Scale 07 — System

HNSCC

Head and neck SCC; HPV+ oropharyngeal HNSCC (TP53 WT, PI3K-active) has better prognosis than HPV-negative (TP53 ~80%, CDKN2A ~40%); cetuximab and pembrolizumab are approved; KEYNOTE-048 defines first-line pembrolizumab over EXTREME in PD-L1+ recurrent/metastatic disease.

Also known as: HNSCC, head and neck squamous cell carcinoma, oral cavity cancer, oropharyngeal cancer, HPV-positive HNSCC, laryngeal cancer, hypopharyngeal cancer, head and neck cancer

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hnscc

HNSCC

Head and neck SCC; HPV+ oropharyngeal HNSCC (TP53 WT, PI3K-active) has better prognosis than HPV-negative (TP53 ~80%, CDKN2A ~40%); cetuximab and pembrolizumab are approved; KEYNOTE-048 defines first-line pembrolizumab over EXTREME in PD-L1+ recurrent/metastatic disease.

Entry Metadata

FieldValue
IDhnscc
NameHNSCC
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toEgfr connects-toPd 1 connects-toP53 connects-toPik3Ca connects-toEpstein Barr Virus connects-toRb1 connects-toCdkn2A connects-toEsophageal Cancer connects-toCervical Cancer connects-toT Cytotoxic Cell connects-toAlcohol Use Disorder connects-toCarbon connects-toHpv 16 connects-toPhoton connects-toFibroblast connects-toThyroid Cancer connects-toNsclc connects-toMacrophage connects-toVegf connects-toTert connects-toLymphatic System connects-toImmune System connects-toProton connects-toB Cell connects-toLung connects-toCyclin D1 connects-toNatural Killer Cell connects-toRegulatory T Cell connects-toOxygen connects-toNf Kb connects-toDendritic Cell connects-toIron connects-toFibrosis connects-toEndothelial Cell connects-toZinc connects-toNeuron connects-toLiver connects-toElectron connects-toBone Marrow connects-toEye connects-toAntibody connects-toMagnesium connects-toStomach connects-toReproductive System connects-toThyroid connects-toPlatelet connects-toAkt connects-toNeutrophil connects-toBladder Cancer connects-toStat3 connects-toMast Cell connects-toSepsis connects-toCandida Albicans connects-toStroke connects-toVenous Thromboembolism connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toAspergillus Fumigatus connects-toNeuropathic Pain connects-toWound Healing connects-toStreptococcus Pneumoniae connects-toDigestive System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toNervous System connects-toCardiovascular System connects-toMusculoskeletal System connects-toRenal System connects-toIntegumentary System connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toCortical Bone connects-toTargeted Therapy connects-toGerminal Center connects-toCurcumin connects-toPeripheral Nerve connects-toAlveolus connects-toArterial Wall connects-toDermatomyositis connects-toAplastic Anemia connects-toGvhd connects-toNotch connects-toFgfr connects-toYap1 connects-toMyc connects-toHif 1Alpha connects-toEzh2 connects-toTgf Beta connects-toMet connects-toCcl2 connects-toCgas Sting connects-toCxcl12 connects-toPerforin connects-toE2F1 connects-toCaspase 3 connects-toImmunoglobulin G connects-toErk1 2 connects-toMtor connects-toNfe2L2 connects-toIl 6 connects-toKras connects-toBcl 2 connects-toJak1 2 connects-toSmad4 connects-toGalectin 3 connects-toStat1 connects-toCdk4 6 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toAxl Receptor connects-toHemoglobin connects-toXanthine Oxidase connects-toIl 10 connects-toProstaglandins connects-toIl 4 connects-toNitric Oxide connects-toIl 13 connects-toLung connects-toIron connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toIl 5 connects-toIge connects-toPlasma Cell connects-toT Helper Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTslp connects-toPeriostin connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toPotassium connects-toCalcium connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources