Atlas One · Host Biology · Scale 07 — System

Cervical Cancer

Cervical cancer is HPV-driven in >99% of cases; HPV E6/E7 oncoproteins degrade p53 and inactivate RB → immortalization. Cisplatin + chemoradiation is standard for locally advanced; pembrolizumab + chemotherapy (KEYNOTE-826) is approved for PD-L1+ recurrent/metastatic disease.

Also known as: cervical cancer, cervical carcinoma, HPV cervical cancer, squamous cell carcinoma cervix, cervical adenocarcinoma, FIGO cervical cancer, invasive cervical cancer

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cervical-cancer

Cervical Cancer

Cervical cancer is HPV-driven in >99% of cases; HPV E6/E7 oncoproteins degrade p53 and inactivate RB → immortalization. Cisplatin + chemoradiation is standard for locally advanced; pembrolizumab + chemotherapy (KEYNOTE-826) is approved for PD-L1+ recurrent/metastatic disease.

Entry Metadata

FieldValue
IDcervical-cancer
NameCervical Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPd 1 connects-toRb1 connects-toP53 connects-toVegf connects-toHpv 16 connects-toPik3Ca connects-toKras connects-toHnscc connects-toHiv Aids connects-toT Cytotoxic Cell connects-toBladder Cancer connects-toEndometrial Cancer connects-toOvarian Cancer connects-toPeutz Jeghers Syndrome connects-toPhoton connects-toDendritic Cell connects-toImmune System connects-toNatural Killer Cell connects-toTert connects-toReproductive System connects-toLymphatic System connects-toCarbon connects-toB Cell connects-toKidney connects-toPlacenta connects-toCdkn2A connects-toEgfr connects-toRegulatory T Cell connects-toOxygen connects-toType I Interferon connects-toLung connects-toIron connects-toLarge Intestine connects-toFibrosis connects-toEndothelial Cell connects-toLiver connects-toBone Marrow connects-toElectron connects-toBrain connects-toVitamin D connects-toAntibody connects-toErythrocyte connects-toNeuron connects-toT Helper Cell connects-toEstrogen connects-toZinc connects-toCkd connects-toIl 6 connects-toMacrophage connects-toNf Kb connects-toFibroblast connects-toVenous Thromboembolism connects-toStat3 connects-toSepsis connects-toAnemia Of Chronic Disease connects-toHiv connects-toIron Deficiency Anemia connects-toMajor Depressive Disorder connects-toNeuropathic Pain connects-toOsteoporosis connects-toAspergillus Fumigatus connects-toRenal System connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toMusculoskeletal System connects-toNervous System connects-toCardiovascular System connects-toIntegumentary System connects-toHerpesvirus connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toHiv 1 connects-toTargeted Therapy connects-toCortical Bone connects-toGlomerulus connects-toAlveolus connects-toGerminal Center connects-toHer2 connects-toGvhd connects-toColorectal Cancer connects-toCovid 19 Disease connects-toMyc connects-toNotch connects-toIntestinal Epithelium connects-toAkt connects-toHif 1Alpha connects-toEzh2 connects-toMtor connects-toTgf Beta connects-toCcl2 connects-toCgas Sting connects-toPerforin connects-toCxcl12 connects-toE2F1 connects-toCaspase 3 connects-toImmunoglobulin G connects-toPten connects-toErk1 2 connects-toCdh1 connects-toJak1 2 connects-toNfe2L2 connects-toWnt Beta Catenin connects-toSmad4 connects-toGalectin 3 connects-toCyclin D1 connects-toStat1 connects-toFoxo connects-toPdgf connects-toS100A8 A9 connects-toGsk 3B connects-toMdm2 connects-toCdk4 6 connects-toSrc Kinase connects-toDnmt3A connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toSecretory Iga connects-toAxl Receptor connects-toIl 2 connects-toHemoglobin connects-toIl 10 connects-toProstaglandins connects-toXanthine Oxidase connects-toNitric Oxide connects-toIl 4 connects-toIl 13 connects-toSelenium connects-toLeptin connects-toAdiponectin connects-toResistin connects-toEndometrial Cancer connects-toOvarian Cancer connects-toT Helper Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toMast Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toOsteopontin connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toCalcium connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin

Sources