Atlas One · Host Biology · Scale 03 — Molecular

CDH1

E-cadherin (CDH1) is the epithelial adhesion molecule and Wnt/β-catenin co-regulator. CDH1 loss → EMT and invasive growth; germline CDH1 mutations cause hereditary diffuse gastric cancer (HDGC) with 70-80% lifetime risk; CDH1 promoter methylation is common in sporadic tumors.

Also known as: CDH1, E-cadherin, E-cad, cadherin-1, hereditary diffuse gastric cancer, HDGC, E-cadherin loss, CDH1 mutation, uvomorulin

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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cdh1

CDH1

E-cadherin (CDH1) is the epithelial adhesion molecule and Wnt/β-catenin co-regulator. CDH1 loss → EMT and invasive growth; germline CDH1 mutations cause hereditary diffuse gastric cancer (HDGC) with 70-80% lifetime risk; CDH1 promoter methylation is common in sporadic tumors.

Entry Metadata

FieldValue
IDcdh1
NameCDH1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toWnt Beta Catenin connects-toTgf Beta connects-toP53 connects-toSrc Kinase connects-toGastric Cancer connects-toBreast Cancer connects-toMet

Sources