Atlas One · Host Biology · Scale 03 — Molecular

Renin

Renin (juxtaglomerular cell aspartyl protease) cleaves angiotensinogen to angiotensin I → ACE → angiotensin II → vasoconstriction and aldosterone; RAAS overactivation drives hypertension; suppressed renin plus elevated aldosterone diagnoses primary aldosteronism.

Also known as: renin, REN, RAAS, renin-angiotensin system, angiotensin converting enzyme, angiotensinogen, prorenin, aliskiren, juxtaglomerular, plasma renin activity, PRA, ARR, direct renin inhibitor

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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renin

Renin

Renin (juxtaglomerular cell aspartyl protease) cleaves angiotensinogen to angiotensin I → ACE → angiotensin II → vasoconstriction and aldosterone; RAAS overactivation drives hypertension; suppressed renin plus elevated aldosterone diagnoses primary aldosteronism.

Entry Metadata

FieldValue
IDrenin
NameRenin
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHypertension connects-toAngiotensin Ii connects-toAldosterone connects-toCkd connects-toEpinephrine connects-toCortisol connects-toHif 1Alpha

Sources