Atlas One · Host Biology · Scale 07 — System

Chronic Kidney Disease

Progressive irreversible loss of kidney function (GFR <60 mL/min for >3 months) from diabetes, hypertension, or glomerulonephritis. Staged G1-G5 by GFR; complications include anemia, hyperparathyroidism, and uremia. End-stage managed by dialysis or transplantation.

Also known as: CKD, chronic renal failure, chronic renal insufficiency, end-stage kidney disease, ESKD

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ckd

Chronic Kidney Disease

Progressive irreversible loss of kidney function (GFR <60 mL/min for >3 months) from diabetes, hypertension, or glomerulonephritis. Staged G1-G5 by GFR; complications include anemia, hyperparathyroidism, and uremia. End-stage managed by dialysis or transplantation.

Entry Metadata

FieldValue
IDckd
NameChronic Kidney Disease
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsKidney part-ofRenal System modulatesErythropoietin connects-toHypertension connects-toSglt2 connects-toFgf23 connects-toOsteopontin connects-toIga Nephropathy connects-toHepcidin connects-toAnemia Of Chronic Disease connects-toAhus connects-toSickle Cell Disease connects-toMalaria connects-toSclerostin connects-toPrurigo Nodularis connects-toType 2 Diabetes connects-toAtherosclerosis connects-toCalcium connects-toPodocyte connects-toGlomerulus connects-toCardiovascular System connects-toPotassium connects-toHeart Failure connects-toVitamin D connects-toFibrosis connects-toPhosphorus connects-toAngiotensin Ii connects-toHeart connects-toAldosterone connects-toOsteoclast connects-toHydrogen connects-toBrain connects-toEndothelial Cell connects-toPhoton connects-toSkin connects-toFibroblast connects-toElectron connects-toErythrocyte connects-toMagnesium connects-toPth connects-toHemoglobin connects-toPlatelet connects-toSodium connects-toAntibody connects-toReproductive System connects-toRenin connects-toMacrophage connects-toGout connects-toTgf Beta connects-toStroke connects-toRenal Cell Carcinoma connects-toNf Kb connects-toSepsis connects-toVenous Thromboembolism connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toPulmonary Arterial Hypertension connects-toStaphylococcus Aureus connects-toWound Healing connects-toNeuropathic Pain connects-toEndocrine System connects-toDigestive System connects-toImmune System connects-toNervous System connects-toRespiratory System connects-toMusculoskeletal System connects-toIntegumentary System connects-toHepatitis B Virus connects-toTuberculosis connects-toAce Inhibitors connects-toDietary Fiber connects-toHepatitis C Virus connects-toCortical Bone connects-toArterial Wall connects-toStatins connects-toMyocardium connects-toMultiple Myeloma connects-toSystemic Lupus Erythematosus connects-toType 1 Diabetes connects-toObesity connects-toBone Marrow connects-toCardiac Conduction System connects-toCovid 19 Disease connects-toEpilepsy connects-toNitric Oxide connects-toEndothelin 1 connects-toTnf Alpha connects-toCcl2 connects-toVegf connects-toComplement C3 connects-toHif 1Alpha connects-toIl 6 connects-toCholesterol connects-toCalcium connects-toGlp 1 connects-toXanthine Oxidase connects-toWnt Beta Catenin connects-toSmad4 connects-toNlrp3 Inflammasome connects-toNfe2L2 connects-toMtor connects-toMyd88 connects-toGalectin 3 connects-toAkt connects-toPdgf connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toErk1 2 connects-toS100A8 A9 connects-toGsk 3B connects-toPik3Ca connects-toPerforin connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toDnmt3A connects-toCcr5 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toProton connects-toMagnesium connects-toInsulin connects-toTroponin Complex connects-toMu Opioid Receptor connects-toSecretory Iga connects-toIron connects-toProstaglandins connects-toIl 10 connects-toSodium connects-toIron connects-toHypertension connects-toIl 13 connects-toIl 4 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toLiver connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toMast Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toZinc connects-toCopper connects-toIodine connects-toChloride connects-toCarbon connects-toSulfur connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toRankl connects-toIl 2 connects-toFibronectin connects-toIgf 1 connects-toNotch connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toMyostatin connects-toAngiopoietin connects-toCortisol