Atlas One · Host Biology · Scale 07 — System

Multiple Myeloma

Plasma cell malignancy driven by CCND1 translocations (t(11;14)), RAS-MAPK mutations, and MYC. Bortezomib, lenalidomide, and daratumumab transformed outcomes; venetoclax is active in t(11;14) MM; BCMA-targeted CAR-T (cilta-cel, ide-cel) and bispecifics (teclistamab) are approved.

Also known as: MM, myeloma, plasma cell myeloma, Kahler disease, RRMM, relapsed/refractory myeloma, smoldering myeloma, MGUS, PCM

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
multiple-myeloma

Multiple Myeloma

Plasma cell malignancy driven by CCND1 translocations (t(11;14)), RAS-MAPK mutations, and MYC. Bortezomib, lenalidomide, and daratumumab transformed outcomes; venetoclax is active in t(11;14) MM; BCMA-targeted CAR-T (cilta-cel, ide-cel) and bispecifics (teclistamab) are approved.

Entry Metadata

FieldValue
IDmultiple-myeloma
NameMultiple Myeloma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toIl 6 connects-toMyc connects-toBcl 2 connects-toVegf connects-toRankl connects-toSclerostin connects-toCxcl12 connects-toPlasma Cell connects-toBone Marrow connects-toKidney connects-toWaldenstrom Macroglobulinemia connects-toOsteoblast connects-toImmunoglobulin G connects-toCalcium connects-toOsteoporosis connects-toPhoton connects-toB Cell connects-toOsteoclast connects-toDlbcl connects-toErythrocyte connects-toImmune System connects-toLymphatic System connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toNf Kb connects-toAutophagy connects-toMacrophage connects-toDendritic Cell connects-toOxygen connects-toHeart connects-toLiver connects-toIron connects-toPeripheral Nerve connects-toSkin connects-toElectron connects-toSodium connects-toSpleen connects-toLung connects-toBrain connects-toPotassium connects-toAntibody connects-toNeutrophil connects-toAlbumin connects-toVenous Thromboembolism connects-toCyclin D1 connects-toCardiomyocyte connects-toMtor connects-toCkd connects-toAdipocyte connects-toStreptococcus Pneumoniae connects-toNeuropathic Pain connects-toHeart Failure connects-toStat3 connects-toSepsis connects-toAnemia Of Chronic Disease connects-toPneumocystis Jirovecii connects-toHepatitis B Virus connects-toMajor Depressive Disorder connects-toVaricella Zoster Virus connects-toAspergillus Fumigatus connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toNervous System connects-toEndocrine System connects-toCardiovascular System connects-toIntegumentary System connects-toDigestive System connects-toRespiratory System connects-toTargeted Therapy connects-toReproductive System connects-toCortical Bone connects-toCorticosteroids connects-toCll connects-toCar T connects-toGlomerulus connects-toMds connects-toMyocardium connects-toCytokine Storm connects-toHepatic Lobule connects-toCovid 19 Disease connects-toAml connects-toStroke connects-toAkt connects-toNotch connects-toEzh2 connects-toCdk4 6 connects-toTnf Alpha connects-toHif 1Alpha connects-toBaff connects-toCaspase 3 connects-toCcl2 connects-toFgfr connects-toIl 1B connects-toHepcidin connects-toPerforin connects-toComplement C3 connects-toCalcium connects-toKras connects-toP53 connects-toPik3Ca connects-toJak1 2 connects-toNfe2L2 connects-toErk1 2 connects-toTgf Beta connects-toGalectin 3 connects-toPten connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toSrc Kinase connects-toDnmt3A connects-toS100A8 A9 connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 33 connects-toIl 17A connects-toIl 10 connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toHemoglobin connects-toIl 2 connects-toMhc Class Ii connects-toXanthine Oxidase connects-toTroponin Complex connects-toSecretory Iga connects-toProstaglandins connects-toIl 4 connects-toNitric Oxide connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toRegulatory T Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toErythropoietin connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toC5Ar1 connects-toVitamin D connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toHistamine connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin