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sepsis
Sepsis
Life-threatening organ dysfunction from dysregulated host response to infection (Sepsis-3: SOFA ≥2). LPS triggers TLR4→NF-κB and NLRP3 inflammasome; cytokine storm causes vasodilation, DIC, and organ failure. Mortality 20–30%; treated with antibiotics and vasopressors.
Entry Metadata
| Field | Value |
|---|---|
| ID | sepsis |
| Name | Sepsis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. · PubMed 26903338
- van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17(7):407-420. · PubMed 28436424
- Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Intensive Care Med. 2021;47(11):1181-1247. · PubMed 34599691