Atlas One · Host Biology · Scale 07 — System

Sepsis

Life-threatening organ dysfunction from dysregulated host response to infection (Sepsis-3: SOFA ≥2). LPS triggers TLR4→NF-κB and NLRP3 inflammasome; cytokine storm causes vasodilation, DIC, and organ failure. Mortality 20–30%; treated with antibiotics and vasopressors.

Also known as: septicemia, bacteremia, septic shock, SIRS, systemic inflammatory response syndrome

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
sepsis

Sepsis

Life-threatening organ dysfunction from dysregulated host response to infection (Sepsis-3: SOFA ≥2). LPS triggers TLR4→NF-κB and NLRP3 inflammasome; cytokine storm causes vasodilation, DIC, and organ failure. Mortality 20–30%; treated with antibiotics and vasopressors.

Entry Metadata

FieldValue
IDsepsis
NameSepsis
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCytokine Storm connects-toNlrp3 Inflammasome connects-toNf Kb connects-toTnf Alpha connects-toAdrenomedullin connects-toTlr4 connects-toIl 10 connects-toAngiopoietin connects-toTroponin Complex connects-toC1 Esterase Inhibitor connects-toProtein C treated-byVancomycin connects-toDisseminated Intravascular Coagulation connects-toEndothelial Cell connects-toNeutrophil connects-toNitric Oxide connects-toKidney connects-toEscherichia Coli connects-toMacrophage connects-toArds connects-toStreptococcus Pneumoniae connects-toStaphylococcus Aureus connects-toLiver connects-toPlatelet connects-toLung connects-toVasopressin connects-toT Cytotoxic Cell connects-toOxygen connects-toHeart connects-toRegulatory T Cell connects-toBrain connects-toHydrogen connects-toT Helper Cell connects-toPhoton connects-toBone Marrow connects-toAdrenal Gland connects-toElectron connects-toLarge Intestine connects-toCalcium connects-toSkin connects-toMusculoskeletal System connects-toErythrocyte connects-toIl 6 connects-toComplement C5 connects-toReproductive System connects-toBradykinin connects-toCandida Albicans connects-toDendritic Cell connects-toCortisol connects-toNeisseria Meningitidis connects-toSpleen connects-toCkd connects-toHeart Failure connects-toVenous Thromboembolism connects-toStreptococcus Pyogenes connects-toStroke connects-toMajor Depressive Disorder connects-toPtsd connects-toNeuropathic Pain connects-toWound Healing connects-toImmune System connects-toRespiratory System connects-toDigestive System connects-toCardiovascular System connects-toNervous System connects-toEndocrine System connects-toRenal System connects-toIntegumentary System connects-toLymphatic System connects-toCorticosteroids connects-toNorepinephrine connects-toListeria Monocytogenes connects-toMyocardium connects-toAlveolus connects-toHepatic Lobule connects-toSickle Cell Disease connects-toGlomerulus connects-toIntestinal Epithelium connects-toArterial Wall connects-toType 2 Diabetes connects-toCovid 19 Disease connects-toPeripheral Nerve connects-toAlzheimers Disease connects-toCardiac Conduction System connects-toIl 1B connects-toIfn Gamma connects-toFibrinogen connects-toS100A8 A9 connects-toPd 1 connects-toCcl2 connects-toThrombin connects-toRage connects-toCgas Sting connects-toGlucocorticoid Receptor connects-toCaspase 3 connects-toVegf connects-toHif 1Alpha connects-toComplement C3 connects-toBcl 2 connects-toMyd88 connects-toJak1 2 connects-toIl 17A connects-toStat3 connects-toMtor connects-toGalectin 3 connects-toStat1 connects-toAkt connects-toSmad4 connects-toFoxo connects-toErk1 2 connects-toPerforin connects-toGsk 3B connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toMhc Class Ii connects-toHepcidin connects-toVon Willebrand Factor connects-toProton connects-toXanthine Oxidase connects-toHemoglobin connects-toProstaglandins connects-toHistamine connects-toAldosterone connects-toNeutrophil connects-toKidney connects-toLung connects-toCalcium connects-toType I Interferon connects-toIron connects-toKidney connects-toMacrophage connects-toCovid 19 Disease connects-toResistin connects-toLeptin connects-toAdiponectin connects-toIl 12 connects-toIl 4 connects-toIl 13 connects-toC5Ar1 connects-toFactor H connects-toNatural Killer Cell connects-toTransferrin connects-toOsteopontin connects-toMast Cell connects-toTslp connects-toErythropoietin connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toZinc connects-toCopper connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toNitrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toInsulin Receptor connects-toAndrogen Receptor connects-toSubstance P connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources