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rage
RAGE
RAGE is a multiligand immunoglobulin receptor activated by advanced glycation end products, HMGB1, and S100 proteins → NF-κB and NADPH oxidase → chronic inflammation; hyperglycemia-driven AGE-RAGE signaling underlies diabetic angiopathy, NASH, and Alzheimer disease.
Entry Metadata
| Field | Value |
|---|---|
| ID | rage |
| Name | RAGE |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Schmidt AM, Yan SD, Yan SF, Stern DM. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest. 2001;108(7):949-955. · PubMed 11581294
- Deane R, Du Yan S, Submamaryan RK, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003;9(7):907-913. · PubMed 12808450