Atlas One · Host Biology · Scale 03 — Molecular

Protein C

Protein C (PROC; chr2q14.3) is a vitamin K–dependent anticoagulant zymogen; thrombin-thrombomodulin → APC; APC + Protein S inactivate FVa and FVIIIa → brakes thrombin. Deficiency → inherited thrombophilia; FV Leiden R506Q blocks APC cleavage → most common inherited thrombophilia.

Also known as: protein C, PROC, APC, activated protein C, anticoagulant protein C, PC, drotrecogin alfa

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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protein-c

Protein C

Protein C (PROC; chr2q14.3) is a vitamin K–dependent anticoagulant zymogen; thrombin-thrombomodulin → APC; APC + Protein S inactivate FVa and FVIIIa → brakes thrombin. Deficiency → inherited thrombophilia; FV Leiden R506Q blocks APC cleavage → most common inherited thrombophilia.

Entry Metadata

FieldValue
IDprotein-c
NameProtein C
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toInherited Thrombophilia connects-toThrombin connects-toVenous Thromboembolism connects-toSepsis connects-toEndothelial Cell connects-toSickle Cell Disease connects-toHemophilia A

Sources