Atlas One · Host Biology · Scale 07 — System

Sickle Cell Disease

Sickle cell disease (SCD; HbS β-globin E6V; chr11p15.4) is a haemoglobinopathy causing HbS polymerization → RBC sickling → haemolytic anaemia, vaso-occlusion, end-organ damage; hydroxyurea ↑ HbF and reduces crises; voxelotor and crizanlizumab are newer FDA-approved therapies.

Also known as: SCD, sickle cell disease, sickle cell anemia, sickle cell anaemia, HbSS, HbSC disease, haemoglobin S disease, sickle-cell anaemia, SCA

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
sickle-cell-disease

Sickle Cell Disease

Sickle cell disease (SCD; HbS β-globin E6V; chr11p15.4) is a haemoglobinopathy causing HbS polymerization → RBC sickling → haemolytic anaemia, vaso-occlusion, end-organ damage; hydroxyurea ↑ HbF and reduces crises; voxelotor and crizanlizumab are newer FDA-approved therapies.

Entry Metadata

FieldValue
IDsickle-cell-disease
NameSickle Cell Disease
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toHemoglobin connects-toStroke connects-toCkd connects-toCardiovascular System connects-toTransferrin connects-toThalassemia connects-toG6Pd connects-toMalaria connects-toProtein C connects-toErythrocyte connects-toSpleen connects-toVenous Thromboembolism connects-toPulmonary Arterial Hypertension connects-toNeuropathic Pain connects-toMacrophage connects-toNitric Oxide connects-toOxygen connects-toKidney connects-toEndothelial Cell connects-toBone Marrow connects-toImmune System connects-toLung connects-toMusculoskeletal System connects-toEye connects-toIron connects-toNeutrophil connects-toLiver connects-toPlatelet connects-toBrain connects-toPotassium connects-toHydrogen connects-toHeart connects-toSmooth Muscle Cell connects-toPhoton connects-toSkin connects-toFibrosis connects-toElectron connects-toZinc connects-toLarge Intestine connects-toReproductive System connects-toAntibody connects-toOsteoblast connects-toStreptococcus Pneumoniae connects-toOsteoclast connects-toMagnesium connects-toIl 6 connects-toAplastic Anemia connects-toSmall Intestine connects-toAdenosine connects-toMast Cell connects-toSepsis connects-toNf Kb connects-toSalmonella Typhi connects-toHcc connects-toOsteoporosis connects-toHeart Failure connects-toOpioid Use Disorder connects-toWound Healing connects-toNeisseria Meningitidis connects-toMajor Depressive Disorder connects-toRespiratory System connects-toDigestive System connects-toIntegumentary System connects-toNervous System connects-toEndocrine System connects-toLymphatic System connects-toRenal System connects-toAce Inhibitors connects-toZinc Dietary connects-toAmoxicillin connects-toStaphylococcus Aureus connects-toIron Deficiency Anemia connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toCortical Bone connects-toAlveolus connects-toGlomerulus connects-toPlacenta connects-toArterial Wall connects-toMyocardium connects-toGerminal Center connects-toRsv connects-toGvhd connects-toCardiac Conduction System connects-toEndothelin 1 connects-toTnf Alpha connects-toHif 1Alpha connects-toTlr4 connects-toS100A8 A9 connects-toVegf connects-toVon Willebrand Factor connects-toPf4 connects-toHepcidin connects-toRage connects-toXanthine Oxidase connects-toComplement C5 connects-toNfe2L2 connects-toNlrp3 Inflammasome connects-toFerroportin connects-toMyd88 connects-toThrombin connects-toAngiopoietin connects-toAkt connects-toErk1 2 connects-toGalectin 3 connects-toCgas Sting connects-toStat3 connects-toSmad4 connects-toFoxo connects-toStat1 connects-toJak1 2 connects-toGsk 3B connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toComplement C3 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toCalcium connects-toMu Opioid Receptor connects-toMhc Class Ii connects-toVitamin D connects-toOmega 3 Fatty Acids connects-toIl 10 connects-toSubstance P connects-toProstaglandins connects-toBradykinin connects-toErythropoietin connects-toIl 4 connects-toLeptin connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toEndothelial Cell connects-toNeutrophil connects-toStroke connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toC5Ar1 connects-toFactor H connects-toT Helper Cell connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toT Cytotoxic Cell connects-toTslp connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources