PF4

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pf4

Platelet Factor 4 (PF4/CXCL4; chr4q13.3) is a CXC chemokine released from platelet alpha-granules; neutralizes heparin; PF4-heparin complexes are the HIT antigen: IgG → FcγRIIA → platelet activation → thrombosis despite thrombocytopenia. Also anti-angiogenic.

Entry Metadata

Field	Value
ID	pf4
Name	PF4
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	03-molecular

Cross-Atlas Connections

connects-toHeparin Induced Thrombocytopenia connects-toPlatelet connects-toThrombin modulatesVegf connects-toNeutrophil connects-toMacrophage

Sources

Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):311S-337S. · PubMed 15383477
Greinacher A, Thiele T, Warkentin TE, et al. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med. 2021;384(22):2092-2101. · PubMed 33835769
Sachais BS, Higazi AAR, Cines DB, Poncz M, Kowalska MA. Interactions of platelet factor 4 with the vessel wall. Semin Thromb Hemost. 2004;30(3):351-358. · PubMed 15246229