Atlas One · Host Biology · Scale 03 — Molecular

Interleukin-10

IL-10 is the master anti-inflammatory cytokine; IL10 gene chr1q32.1; homodimer; IL-10Rα/IL-10Rβ → JAK1/TYK2 → STAT3 → suppresses NF-κB in macrophages, reducing TNF-α, IL-1β, IL-6, IL-12. Treg-derived IL-10 protects against GvHD; IL-10R mutations cause very-early-onset IBD.

Also known as: IL10, cytokine synthesis inhibitory factor, CSIF, B-cell-derived T-cell growth factor, TGIF

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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il-10

Interleukin-10

IL-10 is the master anti-inflammatory cytokine; IL10 gene chr1q32.1; homodimer; IL-10Rα/IL-10Rβ → JAK1/TYK2 → STAT3 → suppresses NF-κB in macrophages, reducing TNF-α, IL-1β, IL-6, IL-12. Treg-derived IL-10 protects against GvHD; IL-10R mutations cause very-early-onset IBD.

Entry Metadata

FieldValue
IDil-10
NameInterleukin-10
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toGvhd connects-toAtopic Dermatitis connects-toNash connects-toInflammatory Bowel Disease connects-toSepsis connects-toImmune System

Sources