Atlas One · Host Biology · Scale 07 — System

Atopic Dermatitis

Chronic relapsing type 2 inflammatory skin disease; IL-4/IL-13 → STAT6 → filaggrin and barrier protein suppression → epidermal barrier failure and Th2 sensitization; dupilumab (anti-IL-4Rα) and JAK1 inhibitors (upadacitinib) are first-line biologics.

Also known as: atopic dermatitis, AD, eczema, atopic eczema, IgE-mediated dermatitis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
atopic-dermatitis

Atopic Dermatitis

Chronic relapsing type 2 inflammatory skin disease; IL-4/IL-13 → STAT6 → filaggrin and barrier protein suppression → epidermal barrier failure and Th2 sensitization; dupilumab (anti-IL-4Rα) and JAK1 inhibitors (upadacitinib) are first-line biologics.

Entry Metadata

FieldValue
IDatopic-dermatitis
NameAtopic Dermatitis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

modulated-byIl 4 connects-toIge connects-toTgf Beta connects-toIl 17A modulated-byIl 13 connects-toIl 33 connects-toIl 31 connects-toPrurigo Nodularis connects-toIl 10 connects-toPeriostin connects-toSkin connects-toAsthma connects-toStaphylococcus Aureus connects-toPsoriasis connects-toT Helper Cell connects-toDendritic Cell connects-toHistamine connects-toMast Cell connects-toTslp connects-toJak1 2 connects-toIntegumentary System connects-toNervous System connects-toB Cell connects-toGut Microbiome connects-toVitamin D connects-toCortisol connects-toRegulatory T Cell connects-toZinc connects-toNeuron connects-toSubstance P connects-toCalcium connects-toPhoton connects-toEye connects-toLarge Intestine connects-toPeripheral Nerve connects-toLung connects-toFibroblast connects-toElectron connects-toBrain connects-toHeart connects-toAntibody connects-toMelatonin connects-toNeutrophil connects-toMajor Depressive Disorder connects-toReproductive System connects-toFibrosis connects-toIl 5 connects-toCandida Albicans connects-toGeneralized Anxiety Disorder connects-toInsomnia Disorder connects-toNlrp3 Inflammasome connects-toSocial Anxiety Disorder connects-toStat3 connects-toNf Kb connects-toSepsis connects-toAttention Deficit Hyperactivity Disorder connects-toObesity connects-toType 2 Diabetes connects-toWound Healing connects-toStreptococcus Pyogenes connects-toObsessive Compulsive Disorder connects-toImmune System connects-toHerpesvirus connects-toEndocrine System connects-toRespiratory System connects-toLymphatic System connects-toCardiovascular System connects-toDigestive System connects-toCorticosteroids connects-toCoxsackievirus B connects-toOmega 3 Fatty Acids connects-toInflammatory Bowel Disease connects-toAtherosclerosis connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toIntestinal Epithelium connects-toGerminal Center connects-toSynapse connects-toPlasma Cell connects-toRsv connects-toAutism Spectrum Disorder connects-toOsteoporosis connects-toVaricella Zoster Virus connects-toLeptin connects-toType 1 Diabetes connects-toCgrp connects-toTnf Alpha connects-toIl 6 connects-toEgfr connects-toVegf connects-toCcl2 connects-toNtrk connects-toKit connects-toCholesterol connects-toGlucocorticoid Receptor connects-toCalcium connects-toAcetylcholine connects-toCaspase 3 connects-toIl 1B connects-toNfe2L2 connects-toTlr4 connects-toIl 23 connects-toMtor connects-toAkt connects-toGalectin 3 connects-toErk1 2 connects-toStat1 connects-toSmad4 connects-toCgas Sting connects-toFoxo connects-toS100A8 A9 connects-toPerforin connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toComplement C3 connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toMhc Class Ii connects-toEstrogen connects-toNitric Oxide connects-toProgesterone connects-toMacrophage connects-toXanthine Oxidase connects-toProstaglandins connects-toSerotonin connects-toInsulin connects-toSelenium connects-toResistin connects-toCopper connects-toAdiponectin connects-toPsoriasis connects-toSelenium connects-toMast Cell connects-toDendritic Cell connects-toPrurigo Nodularis connects-toIfn Gamma connects-toIl 12 connects-toNatural Killer Cell connects-toType I Interferon connects-toComplement C5 connects-toC5Ar1 connects-toT Cytotoxic Cell connects-toFactor H connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toCollagen connects-toTransferrin connects-toBradykinin connects-toErythropoietin connects-toProlactin connects-toTestosterone connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toPhosphorus connects-toIron connects-toNitrogen connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toOxygen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toNorepinephrine connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources