Atlas One · Host Biology · Scale 07 — System

Atopic Dermatitis

Chronic relapsing type 2 inflammatory skin disease; IL-4/IL-13 → STAT6 → filaggrin and barrier protein suppression → epidermal barrier failure and Th2 sensitization; dupilumab (anti-IL-4Rα) and JAK1 inhibitors (upadacitinib) are first-line biologics.

Also known as: atopic dermatitis, AD, eczema, atopic eczema, IgE-mediated dermatitis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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atopic-dermatitis

Atopic Dermatitis

Chronic relapsing type 2 inflammatory skin disease; IL-4/IL-13 → STAT6 → filaggrin and barrier protein suppression → epidermal barrier failure and Th2 sensitization; dupilumab (anti-IL-4Rα) and JAK1 inhibitors (upadacitinib) are first-line biologics.

Entry Metadata

FieldValue
IDatopic-dermatitis
NameAtopic Dermatitis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

modulated-byIl 4 connects-toIge connects-toTgf Beta connects-toIl 17A modulated-byIl 13 connects-toIl 33 connects-toIl 31 connects-toPrurigo Nodularis connects-toIl 10 connects-toPeriostin

Sources