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social-anxiety-disorder
Social Anxiety Disorder
Social anxiety disorder (12% lifetime) involves amygdala hyperreactivity to social threat and striatal dopamine deficit impairing social reward; first-line: SSRIs/SNRIs + CBT with social exposure; β-blockers for performance-only type; MAOIs for severe refractory cases.
Entry Metadata
| Field | Value |
|---|---|
| ID | social-anxiety-disorder |
| Name | Social Anxiety Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toSerotonin
connects-toDopamine
connects-toNorepinephrine
connects-toGaba
targetsBrain
connects-toOxytocin
connects-toGeneralized Anxiety Disorder
connects-toMajor Depressive Disorder
connects-toAlcohol Use Disorder
connects-toPanic Disorder
connects-toAutism Spectrum Disorder
connects-toInternet Gaming Disorder
connects-toPtsd
connects-toObsessive Compulsive Disorder
connects-toNeuron
connects-toCortisol
connects-toInsomnia Disorder
connects-toAnorexia Nervosa
connects-toSerotonin Transporter
connects-toNervous System
connects-toCannabis Use Disorder
connects-toEpinephrine
connects-toBdnf
connects-toHippocampus
connects-toHeart
connects-toAdenosine
connects-toMicroglia
connects-toAdrenal Gland
connects-toSynapse
connects-toMagnesium
connects-toSkin
connects-toCalcium
connects-toAstrocyte
connects-toPhoton
connects-toLung
connects-toPeripheral Nerve
connects-toZinc
connects-toStomach
connects-toVitamin D
connects-toAcetylcholine
connects-toMelatonin
connects-toReproductive System
connects-toEndocannabinoid
connects-toGut Microbiome
connects-toLarge Intestine
connects-toCrh
connects-toThyroid
connects-toBipolar Disorder
connects-toGlutamate
connects-toStimulant Use Disorder
connects-toPsoriasis
connects-toNf Kb
connects-toSchizophrenia
connects-toCardiovascular System
connects-toObesity
connects-toBinge Eating Disorder
connects-toFibromyalgia
connects-toAsthma
connects-toHypertension
connects-toType 2 Diabetes
connects-toIntegumentary System
connects-toDigestive System
connects-toAttention Deficit Hyperactivity Disorder
connects-toEndocrine System
connects-toMusculoskeletal System
connects-toRespiratory System
connects-toFluoxetine
connects-toBeta Blockers
connects-toImmune System
connects-toAshwagandha
connects-toOmega 3 Fatty Acids
connects-toBulimia Nervosa
connects-toBorderline Personality Disorder
connects-toSt Johns Wort
connects-toPanax Ginseng
connects-toCardiac Conduction System
connects-toNpy
connects-toGambling Disorder
connects-toOpioid Use Disorder
connects-toMigraine
connects-toCovid 19 Disease
connects-toIntestinal Epithelium
connects-toAtopic Dermatitis
connects-toParkinsons Disease
connects-toTnf Alpha
connects-toVasopressin
connects-toIl 6
connects-toProgesterone
connects-toSubstance P
connects-toTestosterone
connects-toMu Opioid Receptor
connects-toEstrogen
connects-toIl 1B
connects-toOrexin
connects-toCgrp
connects-toGhrelin
connects-toGlucocorticoid Receptor
connects-toBeta1 Adrenergic Receptor
connects-toErk1 2
connects-toTlr4
connects-toNtrk
connects-toNfe2L2
connects-toAkt
connects-toGalectin 3
connects-toMyd88
connects-toGsk 3B
connects-toStat3
connects-toCgas Sting
connects-toFoxo
connects-toStat1
connects-toJak1 2
connects-toHif 1Alpha
connects-toS100A8 A9
connects-toPik3Ca
connects-toAmpk
connects-toAutophagy
connects-toDnmt3A
connects-toSrc Kinase
connects-toCcr5
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toAngiotensin Ii
connects-toNitric Oxide
connects-toHistamine
connects-toAldosterone
connects-toInsulin
connects-toIl 10
connects-toCholesterol
connects-toProstaglandins
connects-toXanthine Oxidase
connects-toIl 4
connects-toIl 13
connects-toCopper
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toMicroglia
connects-toPanic Disorder
connects-toMagnesium
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toT Cytotoxic Cell
connects-toNatural Killer Cell
connects-toComplement C5
connects-toC5Ar1
connects-toDendritic Cell
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toErythropoietin
connects-toFactor H
connects-toPeriostin
connects-toProlactin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toPotassium
connects-toPhosphorus
connects-toIron
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toCarbon
connects-toHydrogen
connects-toOxygen
connects-toPd 1
connects-toGlp 1
connects-toVegf
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCalcitonin
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toAdrenomedullin
connects-toOsteopontin
connects-toFgfr
connects-toRenin
connects-toMyostatin
connects-toAngiopoietin
Sources
- Liebowitz MR. Social phobia. Mod Probl Pharmacopsychiatry. 1987;22:141-173. · PubMed 2885745
- Stein MB, Stein DJ. Social anxiety disorder. Lancet. 2008;371(9618):1115-1125. · PubMed 18374843
- Goldin PR, Gross JJ. Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder. Emotion. 2010;10(1):83-91. · PubMed 20141305