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borderline-personality-disorder
Borderline Personality Disorder
Borderline personality disorder (2-5% prevalence; 75% female in clinical settings) involves emotional dysregulation, fear of abandonment, and unstable identity driven by amygdala hyperreactivity and PFC hypofunction; first-line: DBT; pharmacotherapy adjunctive only.
Entry Metadata
| Field | Value |
|---|---|
| ID | borderline-personality-disorder |
| Name | Borderline Personality Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toSerotonin
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targetsBrain
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connects-toPtsd
connects-toMajor Depressive Disorder
connects-toDopamine
connects-toObsessive Compulsive Disorder
connects-toBipolar Disorder
connects-toAlcohol Use Disorder
connects-toBulimia Nervosa
connects-toGeneralized Anxiety Disorder
connects-toHippocampus
connects-toSchizophrenia
connects-toAnorexia Nervosa
connects-toOpioid Use Disorder
connects-toNeuron
connects-toAttention Deficit Hyperactivity Disorder
connects-toBdnf
connects-toGlutamate
connects-toGaba
connects-toCannabis Use Disorder
connects-toVasopressin
connects-toInsomnia Disorder
connects-toAutism Spectrum Disorder
connects-toEstrogen
connects-toMicroglia
connects-toTnf Alpha
connects-toMu Opioid Receptor
connects-toSynapse
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connects-toSkin
connects-toPhoton
connects-toAstrocyte
connects-toOligodendrocyte
connects-toHeart
connects-toMagnesium
connects-toSocial Anxiety Disorder
connects-toMelatonin
connects-toLiver
connects-toReproductive System
connects-toIl 6
connects-toLarge Intestine
connects-toCrh
connects-toBinge Eating Disorder
connects-toT Helper Cell
connects-toEndocannabinoid
connects-toFibromyalgia
connects-toType 2 Diabetes
connects-toPanic Disorder
connects-toStimulant Use Disorder
connects-toNervous System
connects-toHepatitis C Virus
connects-toObesity
connects-toSepsis
connects-toMigraine
connects-toHiv Aids
connects-toHypertension
connects-toWound Healing
connects-toEpilepsy
connects-toHepatitis B Virus
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connects-toDigestive System
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connects-toImmune System
connects-toFluoxetine
connects-toMusculoskeletal System
connects-toRenal System
connects-toGambling Disorder
connects-toInternet Gaming Disorder
connects-toOmega 3 Fatty Acids
connects-toSerotonin Transporter
connects-toNeuropathic Pain
connects-toAtherosclerosis
connects-toTestosterone
connects-toSubstance P
connects-toNarcolepsy
connects-toGut Microbiome
connects-toCovid 19 Disease
connects-toCardiac Conduction System
connects-toNpy
connects-toIl 1B
connects-toAcetylcholine
connects-toGlucocorticoid Receptor
connects-toNlrp3 Inflammasome
connects-toIfn Gamma
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connects-toProlactin
connects-toOrexin
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connects-toMtor
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connects-toAkt
connects-toActh
connects-toErk1 2
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connects-toNtrk
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connects-toNfe2L2
connects-toGsk 3B
connects-toGalectin 3
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connects-toJak1 2
connects-toStat1
connects-toFoxo
connects-toCgas Sting
connects-toHif 1Alpha
connects-toS100A8 A9
connects-toPik3Ca
connects-toDnmt3A
connects-toAmpk
connects-toAutophagy
connects-toSrc Kinase
connects-toCcr5
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toNitric Oxide
connects-toLeptin
connects-toHistamine
connects-toAngiotensin Ii
connects-toInsulin
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connects-toGlp 1
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connects-toIl 4
connects-toCopper
connects-toIl 13
connects-toAttention Deficit Hyperactivity Disorder
connects-toResistin
connects-toAdiponectin
connects-toBipolar Disorder
connects-toAttention Deficit Hyperactivity Disorder
connects-toType I Interferon
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Cytotoxic Cell
connects-toMast Cell
connects-toNatural Killer Cell
connects-toDendritic Cell
connects-toComplement C3
connects-toC5Ar1
connects-toFactor H
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toC1 Esterase Inhibitor
connects-toPeriostin
connects-toComplement C5
connects-toTransferrin
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connects-toIron
connects-toIodine
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connects-toOxygen
connects-toPd 1
connects-toVegf
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toAdrenomedullin
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
Sources
- Linehan MM. Cognitive-Behavioral Treatment of Borderline Personality Disorder. Guilford; 1993. · PubMed 8192506
- Siever LJ, Davis KL. A psychobiological perspective on the personality disorders. Am J Psychiatry. 1991;148(12):1647-1658. · PubMed 1957927
- Zanarini MC, Frankenburg FR, Reich DB, Fitzmaurice G. Time to attainment of recovery from borderline personality disorder and stability of recovery: a 10-year prospective follow-up study. Am J Psychiatry. 2010;167(6):663-667. · PubMed 20395399