Atlas One · Host Biology · Scale 07 — System

Obesity

Obesity (BMI ≥30; 650M affected) is driven by genetic (FTO, MC4R), neuroendocrine (leptin resistance), gut-microbiome, and environmental factors; adipose inflammation causes metabolic syndrome; GLP-1 receptor agonists (semaglutide) achieve 15-20% weight loss.

Also known as: obesity, adiposity, BMI, metabolic syndrome, leptin resistance, GLP-1 agonist, semaglutide, tirzepatide, adipose tissue, central obesity

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
obesity

Obesity

Obesity (BMI ≥30; 650M affected) is driven by genetic (FTO, MC4R), neuroendocrine (leptin resistance), gut-microbiome, and environmental factors; adipose inflammation causes metabolic syndrome; GLP-1 receptor agonists (semaglutide) achieve 15-20% weight loss.

Entry Metadata

FieldValue
IDobesity
NameObesity
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toLeptin connects-toGhrelin connects-toGlp 1 connects-toInsulin connects-toGut Microbiome connects-toNpy connects-toGrowth Hormone connects-toTestosterone connects-toThyroid Hormones connects-toMelatonin connects-toAdiponectin connects-toType 2 Diabetes connects-toNash connects-toAdipocyte connects-toAtherosclerosis connects-toEndometrial Cancer connects-toColorectal Cancer connects-toDopamine connects-toHeart connects-toBreast Cancer connects-toMacrophage connects-toHypertension connects-toPancreas connects-toEstrogen connects-toCortisol connects-toHeart Failure connects-toBrain connects-toTnf Alpha connects-toSerotonin connects-toOxygen connects-toKidney connects-toEndothelial Cell connects-toPhoton connects-toFibrosis connects-toNeuron connects-toElectron connects-toLung connects-toMagnesium connects-toLiver connects-toMusculoskeletal System connects-toReproductive System connects-toThyroid connects-toDietary Fiber connects-toMajor Depressive Disorder connects-toIl 6 connects-toT Cytotoxic Cell connects-toGout connects-toResistin connects-toCkd connects-toStroke connects-toNf Kb connects-toStat3 connects-toVenous Thromboembolism connects-toRenal Cell Carcinoma connects-toPsoriasis connects-toAsthma connects-toEsophageal Cancer connects-toPancreatic Cancer connects-toPulmonary Arterial Hypertension connects-toEndocrine System connects-toDigestive System connects-toWound Healing connects-toRespiratory System connects-toIntegumentary System connects-toNervous System connects-toCardiovascular System connects-toImmune System connects-toLymphatic System connects-toRenal System connects-toMetformin connects-toMagnesium Dietary connects-toIslet Of Langerhans connects-toMyocardium connects-toHcc connects-toBinge Eating Disorder connects-toArterial Wall connects-toGlomerulus connects-toCovid 19 Disease connects-toAlzheimers Disease connects-toMultiple Myeloma connects-toThyroid Cancer connects-toHepatic Lobule connects-toCardiac Conduction System connects-toHif 1Alpha connects-toMtor connects-toAmpk connects-toCcl2 connects-toNlrp3 Inflammasome connects-toInsulin Receptor connects-toEndocannabinoid connects-toOrexin connects-toTlr4 connects-toBdnf connects-toFgfr connects-toVegf connects-toAkt connects-toIl 1B connects-toGlucagon connects-toPik3Ca connects-toMyd88 connects-toGsk 3B connects-toJak1 2 connects-toGalectin 3 connects-toComplement C3 connects-toCgas Sting connects-toSmad4 connects-toStat1 connects-toFoxo connects-toS100A8 A9 connects-toErk1 2 connects-toPerforin connects-toSrc Kinase connects-toCdk4 6 connects-toAutophagy connects-toDnmt3A connects-toCcr5 connects-toCxcl12 connects-toIl 17A connects-toIl 33 connects-toArid1A connects-toCalcineurin connects-toOsteopontin connects-toOxytocin connects-toSglt2 connects-toXanthine Oxidase connects-toTroponin Complex connects-toAngiotensin Ii connects-toPcsk9 connects-toCholesterol connects-toAldosterone connects-toIl 10 connects-toIl 4 connects-toProstaglandins connects-toIron connects-toIl 13 connects-toIl 5 connects-toHepcidin connects-toGut Microbiome connects-toAtherosclerosis connects-toPancreas connects-toNatural Killer Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toIge connects-toType I Interferon connects-toT Helper Cell connects-toMast Cell connects-toFibroblast connects-toComplement C5 connects-toC5Ar1 connects-toTransferrin connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toErythropoietin connects-toPeriostin connects-toFactor H connects-toProlactin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toPotassium connects-toZinc connects-toCalcium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toNitrogen connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin

Sources