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obesity
Obesity
Obesity (BMI ≥30; 650M affected) is driven by genetic (FTO, MC4R), neuroendocrine (leptin resistance), gut-microbiome, and environmental factors; adipose inflammation causes metabolic syndrome; GLP-1 receptor agonists (semaglutide) achieve 15-20% weight loss.
Entry Metadata
| Field | Value |
|---|---|
| ID | obesity |
| Name | Obesity |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288-298. · PubMed 30814686
- Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384(11):989-1002. · PubMed 33567185
- Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 2004;101(44):15718-15723. · PubMed 15505215