This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
gout
Gout
Inflammatory arthritis from monosodium urate (MSU) crystal deposition; hyperuricemia → crystals → NLRP3 inflammasome → IL-1beta → neutrophil-driven acute flares. Colchicine, NSAIDs, and IL-1 inhibitors treat flares; allopurinol and febuxostat reduce urate.
Entry Metadata
| Field | Value |
|---|---|
| ID | gout |
| Name | Gout |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Dalbeth N, Choi HK, Joosten LAB, et al. Gout. Nat Rev Dis Primers. 2019;5(1):69. · PubMed 31558729
- Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237-241. · PubMed 16407889
- FitzGerald JD, Dalbeth N, Mikuls T, et al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care Res (Hoboken). 2020;72(6):744-760. · PubMed 32391934