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gout
Gout
Inflammatory arthritis from monosodium urate (MSU) crystal deposition; hyperuricemia → crystals → NLRP3 inflammasome → IL-1beta → neutrophil-driven acute flares. Colchicine, NSAIDs, and IL-1 inhibitors treat flares; allopurinol and febuxostat reduce urate.
Entry Metadata
| Field | Value |
|---|---|
| ID | gout |
| Name | Gout |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toNlrp3 Inflammasome
connects-toMacrophage
connects-toNeutrophil
connects-toNf Kb
connects-toXanthine Oxidase
connects-toIl 1B
treated-byIbuprofen
connects-toHypertension
connects-toKidney
connects-toMusculoskeletal System
connects-toCkd
connects-toObesity
connects-toAtherosclerosis
connects-toSodium
connects-toRheumatoid Arthritis
connects-toType 2 Diabetes
connects-toAlcohol Use Disorder
connects-toHeart
connects-toCalcium
connects-toCardiovascular System
connects-toRenal System
connects-toFibroblast
connects-toNitrogen
connects-toMyeloproliferative Neoplasms
connects-toSkin
connects-toCortisol
connects-toOsteoclast
connects-toAdenosine
connects-toLarge Intestine
connects-toIl 6
connects-toDendritic Cell
connects-toHydrogen
connects-toFibrosis
connects-toMast Cell
connects-toPhoton
connects-toBone Marrow
connects-toEye
connects-toElectron
connects-toLiver
connects-toMagnesium
connects-toStomach
connects-toAdipocyte
connects-toPancreas
connects-toReproductive System
connects-toPsoriasis
connects-toComplement C3
connects-toTnf Alpha
connects-toEndothelial Cell
connects-toSmall Intestine
connects-toInsulin
connects-toPolycythemia Vera
connects-toStroke
connects-toHeart Failure
connects-toSepsis
connects-toVenous Thromboembolism
connects-toNash
connects-toMajor Depressive Disorder
connects-toAnemia Of Chronic Disease
connects-toWound Healing
connects-toStaphylococcus Aureus
connects-toOsteoporosis
connects-toImmune System
connects-toDigestive System
connects-toEndocrine System
connects-toIntegumentary System
connects-toNervous System
connects-toRespiratory System
connects-toCorticosteroids
connects-toQuercetin
connects-toOmega 3 Fatty Acids
connects-toEssential Thrombocythemia
connects-toPsoriatic Arthritis
connects-toCortical Bone
connects-toGlomerulus
connects-toArterial Wall
connects-toMyelofibrosis
connects-toAml
connects-toCardiac Conduction System
connects-toIntestinal Epithelium
connects-toSickle Cell Disease
connects-toPeripheral Nerve
connects-toCovid 19 Disease
connects-toAngiotensin Ii
connects-toLeptin
connects-toCcl2
connects-toSglt2
connects-toHif 1Alpha
connects-toTgf Beta
connects-toS100A8 A9
connects-toComplement C5
connects-toProstaglandins
connects-toTlr4
connects-toNitric Oxide
connects-toCholesterol
connects-toGlucocorticoid Receptor
connects-toCalcium
connects-toRage
connects-toMyd88
connects-toIl 17A
connects-toAdiponectin
connects-toNfe2L2
connects-toJak1 2
connects-toMtor
connects-toGalectin 3
connects-toAkt
connects-toErk1 2
connects-toStat3
connects-toCgas Sting
connects-toSmad4
connects-toFoxo
connects-toStat1
connects-toGsk 3B
connects-toAmpk
connects-toPik3Ca
connects-toAutophagy
connects-toSrc Kinase
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toVegf
connects-toArid1A
connects-toCalcineurin
connects-toOsteopontin
connects-toEstrogen
connects-toTroponin Complex
connects-toBnp
connects-toAldosterone
connects-toGlp 1
connects-toPth
connects-toEndothelin 1
connects-toRenin
connects-toFibrinogen
connects-toIl 4
connects-toIl 13
connects-toResistin
connects-toType I Interferon
connects-toHepcidin
connects-toHistamine
connects-toRankl
connects-toT Helper Cell
connects-toIfn Gamma
connects-toIl 12
connects-toIl 23
connects-toIl 5
connects-toC5Ar1
connects-toBradykinin
connects-toIge
connects-toT Cytotoxic Cell
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toNatural Killer Cell
connects-toPeriostin
connects-toTransferrin
connects-toTslp
connects-toErythropoietin
connects-toMelatonin
connects-toTestosterone
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toCopper
connects-toPotassium
connects-toZinc
connects-toIron
connects-toPhosphorus
connects-toCarbon
connects-toChloride
connects-toOxygen
connects-toSulfur
connects-toPd 1
connects-toWnt Beta Catenin
connects-toIl 2
connects-toNotch
connects-toIgf 1
connects-toFibronectin
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toFgfr
connects-toEpinephrine
connects-toMyostatin
connects-toAngiopoietin
connects-toGhrelin
Sources
- Dalbeth N, Choi HK, Joosten LAB, et al. Gout. Nat Rev Dis Primers. 2019;5(1):69. · PubMed 31558729
- Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237-241. · PubMed 16407889
- FitzGerald JD, Dalbeth N, Mikuls T, et al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care Res (Hoboken). 2020;72(6):744-760. · PubMed 32391934