Atlas One · Host Biology · Scale 07 — System

Gout

Inflammatory arthritis from monosodium urate (MSU) crystal deposition; hyperuricemia → crystals → NLRP3 inflammasome → IL-1beta → neutrophil-driven acute flares. Colchicine, NSAIDs, and IL-1 inhibitors treat flares; allopurinol and febuxostat reduce urate.

Also known as: gouty arthritis, hyperuricemia, tophaceous gout, MSU crystallopathy, podagra

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
gout

Gout

Inflammatory arthritis from monosodium urate (MSU) crystal deposition; hyperuricemia → crystals → NLRP3 inflammasome → IL-1beta → neutrophil-driven acute flares. Colchicine, NSAIDs, and IL-1 inhibitors treat flares; allopurinol and febuxostat reduce urate.

Entry Metadata

FieldValue
IDgout
NameGout
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toNlrp3 Inflammasome connects-toMacrophage connects-toNeutrophil connects-toNf Kb connects-toXanthine Oxidase connects-toIl 1B treated-byIbuprofen connects-toHypertension connects-toKidney connects-toMusculoskeletal System connects-toCkd connects-toObesity connects-toAtherosclerosis connects-toSodium connects-toRheumatoid Arthritis connects-toType 2 Diabetes connects-toAlcohol Use Disorder connects-toHeart connects-toCalcium connects-toCardiovascular System connects-toRenal System connects-toFibroblast connects-toNitrogen connects-toMyeloproliferative Neoplasms connects-toSkin connects-toCortisol connects-toOsteoclast connects-toAdenosine connects-toLarge Intestine connects-toIl 6 connects-toDendritic Cell connects-toHydrogen connects-toFibrosis connects-toMast Cell connects-toPhoton connects-toBone Marrow connects-toEye connects-toElectron connects-toLiver connects-toMagnesium connects-toStomach connects-toAdipocyte connects-toPancreas connects-toReproductive System connects-toPsoriasis connects-toComplement C3 connects-toTnf Alpha connects-toEndothelial Cell connects-toSmall Intestine connects-toInsulin connects-toPolycythemia Vera connects-toStroke connects-toHeart Failure connects-toSepsis connects-toVenous Thromboembolism connects-toNash connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toWound Healing connects-toStaphylococcus Aureus connects-toOsteoporosis connects-toImmune System connects-toDigestive System connects-toEndocrine System connects-toIntegumentary System connects-toNervous System connects-toRespiratory System connects-toCorticosteroids connects-toQuercetin connects-toOmega 3 Fatty Acids connects-toEssential Thrombocythemia connects-toPsoriatic Arthritis connects-toCortical Bone connects-toGlomerulus connects-toArterial Wall connects-toMyelofibrosis connects-toAml connects-toCardiac Conduction System connects-toIntestinal Epithelium connects-toSickle Cell Disease connects-toPeripheral Nerve connects-toCovid 19 Disease connects-toAngiotensin Ii connects-toLeptin connects-toCcl2 connects-toSglt2 connects-toHif 1Alpha connects-toTgf Beta connects-toS100A8 A9 connects-toComplement C5 connects-toProstaglandins connects-toTlr4 connects-toNitric Oxide connects-toCholesterol connects-toGlucocorticoid Receptor connects-toCalcium connects-toRage connects-toMyd88 connects-toIl 17A connects-toAdiponectin connects-toNfe2L2 connects-toJak1 2 connects-toMtor connects-toGalectin 3 connects-toAkt connects-toErk1 2 connects-toStat3 connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toStat1 connects-toGsk 3B connects-toAmpk connects-toPik3Ca connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toVegf connects-toArid1A connects-toCalcineurin connects-toOsteopontin connects-toEstrogen connects-toTroponin Complex connects-toBnp connects-toAldosterone connects-toGlp 1 connects-toPth connects-toEndothelin 1 connects-toRenin connects-toFibrinogen connects-toIl 4 connects-toIl 13 connects-toResistin connects-toType I Interferon connects-toHepcidin connects-toHistamine connects-toRankl connects-toT Helper Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toIl 5 connects-toC5Ar1 connects-toBradykinin connects-toIge connects-toT Cytotoxic Cell connects-toFactor H connects-toC1 Esterase Inhibitor connects-toNatural Killer Cell connects-toPeriostin connects-toTransferrin connects-toTslp connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toCopper connects-toPotassium connects-toZinc connects-toIron connects-toPhosphorus connects-toCarbon connects-toChloride connects-toOxygen connects-toSulfur connects-toPd 1 connects-toWnt Beta Catenin connects-toIl 2 connects-toNotch connects-toIgf 1 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toMyostatin connects-toAngiopoietin connects-toGhrelin