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bnp
BNP
BNP is a ventricular peptide hormone that activates NPR-A → cGMP → natriuresis and vasodilation, counteracting RAAS in heart failure; plasma BNP/NT-proBNP are gold-standard HF biomarkers; sacubitril inhibits neprilysin → raises natriuretic peptides → reduces HFrEF mortality.
Entry Metadata
| Field | Value |
|---|---|
| ID | bnp |
| Name | BNP |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002;347(3):161-167. · PubMed 12124404
- McMurray JJV, Packer M, Desai AS, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371(11):993-1004. · PubMed 25176015