This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
aldosterone
Aldosterone
Principal mineralocorticoid steroid (zona glomerulosa) that activates MR to upregulate ENaC/Na⁺-K⁺-ATPase, mediating renal Na⁺ retention and K⁺ excretion. Excess aldosterone drives hypertension, cardiac fibrosis, hypokalemia in HF, CKD, and Conn's syndrome.
Entry Metadata
| Field | Value |
|---|---|
| ID | aldosterone |
| Name | Aldosterone |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341(10):709-717. · PubMed 10471456
- Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348(14):1309-1321. · PubMed 12668699
- Funder JW. Mineralocorticoid receptors: distribution and activation. Heart Fail Rev. 2005;10(1):15-22. · PubMed 15947883
- Conn JW. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med. 1955;45(1):3-17. · PubMed 13233623