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ibuprofen
Ibuprofen
Prototype non-selective NSAID; reversibly inhibits COX-1 and COX-2 → ↓ prostaglandin and thromboxane synthesis. Analgesic, antipyretic, anti-inflammatory. Most-consumed OTC analgesic globally. GI and cardiovascular risks limit chronic use. Advil, Nurofen.
Entry Metadata
| Field | Value |
|---|---|
| ID | ibuprofen |
| Name | Ibuprofen |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Stream | 01-modern |
Cross-Atlas Connections
Sources
- Adams SS, Bough RG, Cliffe EE, Lessel B, Mills RF. Absorption, distribution and toxicity of ibuprofen. Toxicol Appl Pharmacol. 1969;15(2):310-30. · PubMed 5351312
- Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231(25):232-5. · PubMed 5284360
- Nussmeier NA, Whelton AA, Brown MT, et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med. 2005;352(11):1081-91. · PubMed 15713945
- Hernandez-Diaz S, Rodriguez LA. Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s. Arch Intern Med. 2000;160(14):2093-9. · PubMed 10904451