Atlas One · Host Biology · Scale 03 — Molecular

MYD88

MYD88 is the universal TLR/IL-1R adaptor protein that activates NF-κB and JAK-STAT3 via IRAK4-TRAF6; MYD88 L265P gain-of-function mutation in ~90% of Waldenström macroglobulinemia and ~25% of ABC-DLBCL drives constitutive NF-κB; ibrutinib highly active in MYD88 L265P WM.

Also known as: MYD88, myeloid differentiation primary response 88, MYD88 L265P, toll-like receptor adaptor, IRAK4, myddosome, TLR signaling adaptor

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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myd88

MYD88

MYD88 is the universal TLR/IL-1R adaptor protein that activates NF-κB and JAK-STAT3 via IRAK4-TRAF6; MYD88 L265P gain-of-function mutation in ~90% of Waldenström macroglobulinemia and ~25% of ABC-DLBCL drives constitutive NF-κB; ibrutinib highly active in MYD88 L265P WM.

Entry Metadata

FieldValue
IDmyd88
NameMYD88
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toNf Kb connects-toJak1 2 connects-toBcl 2 connects-toStat3

Sources