Atlas One · Host Biology · Scale 03 — Molecular

NRF2

NRF2 (NFE2L2) is the master antioxidant transcription factor sequestered by KEAP1; NFE2L2 gain-of-function mutations in ~15% of ESCC and ~15% of LUSC impair KEAP1 binding → constitutive NRF2 → chemotherapy/radiation resistance; no approved NRF2 inhibitor exists.

Also known as: NRF2, NFE2L2, nuclear factor erythroid 2-related factor 2, KEAP1-NRF2, antioxidant response element, ARE, NRF2 cancer, KEAP1 mutation NSCLC, NRF2 esophageal

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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nfe2l2

NRF2

NRF2 (NFE2L2) is the master antioxidant transcription factor sequestered by KEAP1; NFE2L2 gain-of-function mutations in ~15% of ESCC and ~15% of LUSC impair KEAP1 binding → constitutive NRF2 → chemotherapy/radiation resistance; no approved NRF2 inhibitor exists.

Entry Metadata

FieldValue
IDnfe2l2
NameNRF2
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toKras connects-toMtor connects-toHif 1Alpha connects-toP53

Sources