Atlas One · Host Biology · Scale 03 — Molecular

Factor H

Factor H (CFH; chr1q31.3) is the primary soluble regulator of the alternative complement pathway; 20 SCR domains; binds C3b on host surfaces → decay-acceleration + Factor I cofactor → C3b inactivation. CFH mutations → aHUS; Y402H polymorphism → macular degeneration risk.

Also known as: Factor H, CFH, complement Factor H, FH, complement regulator, alternative pathway inhibitor

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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factor-h

Factor H

Factor H (CFH; chr1q31.3) is the primary soluble regulator of the alternative complement pathway; 20 SCR domains; binds C3b on host surfaces → decay-acceleration + Factor I cofactor → C3b inactivation. CFH mutations → aHUS; Y402H polymorphism → macular degeneration risk.

Entry Metadata

FieldValue
IDfactor-h
NameFactor H
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAhus connects-toComplement C3 connects-toComplement C5 connects-toEye connects-toGlomerulus connects-toPnh

Sources